Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives

Zee, R. Y., Scbrader, A. P., Robinson, B. G., Griffiths, Lyn R., & Morris, B. J. (1995) Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives. Clinical Genetics, 47(3), pp. 118-121.

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Abstract

Obese (BMI ≥ 26 kg/m 2; n = 51) and lean (BMI <26 kg/m 2; n = 61) Caucasian patients with severe, familial essential hypertension, were compared with respect to genotype and allele frequencies of a HincII RFLP of the low density lipoprotein receptor gene (LDLR). A similar analysis was performed in obese (n = 28) and lean (n = 68) normotensives. A significant association of the C allele of the T→C variant responsible for this RFLP was seen with obesity (χ 2 = 4.6, P = 0.029) in the hypertensive, but not in the normotensive, group (odds ratio = 3.0 for the CC genotype and 2.7 for CT). Furthermore, BMI tracked with genotypes of this allele in the hypertensives (P = 0.046). No significant genotypic relationship was apparent for plasma lipids. Significant linkage disequilibrium was, moreover, noted between the HincII RFLP and an ApaLI RFLP (χ 2 = 33, P<0.0005) that has previously shown even stronger association with obesity (odds ratio 19.6 for cases homozygous for the susceptibility allele and 15.2 for het-erozygotes). The present study therefore adds to our previous evidence implicating LDLR as a locus for obesity in patients with essential hypertension.

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ID Code: 63200
Item Type: Journal Article
Refereed: Yes
Additional Information: 7634533
Keywords: Body mass index, Chromosome 19, Cross-sectional study, DNA, Etiology, Genetic markers, Low density lipoprotein receptor, PCR, Plasma lipids, RFLP, lipid, low density lipoprotein receptor, adult, allele, article, body mass, caucasian, controlled study, essential hypertension, female, gene frequency, gene linkage disequilibrium, gene locus, genotype, heterozygote, homozygote, human, lipid blood level, major clinical study, male, obesity, priority journal, receptor gene, restriction fragment length polymorphism, risk, Alleles, Body Weight, Cholesterol, Deoxyribonucleases, Type II Site-Specific, Female, Genotype, Heterozygote, Homozygote, Human, Hypertension, Linkage Disequilibrium, Male, Middle Age, Obesity, Phenotype, Point Mutation, Polymorphism, Restriction Fragment Length, Receptors, LDL, Support, Non-U.S. Gov't
ISSN: 0009-9163
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1995 Wiley-Blackwell Publishing, Inc.
Deposited On: 08 Oct 2013 04:14
Last Modified: 08 Oct 2013 04:14

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