Ross River virus evolution : implications for vaccine development

Aaskov, John, Fokine, Andrei, & Liu, Wenjun (2012) Ross River virus evolution : implications for vaccine development. Future Virology, 7(2), pp. 173-178.

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Abstract

Ross River virus is a mosquito-borne alphavirus that causes approximately 5000 cases of epidemic polyarthritis in Australia each year and has direct medical-associated costs of approximately US$15 million annually. While mosquito control programs are able, at best, to contain rather than prevent this disease, natural infection with Ross River virus confers lifelong protection against subsequent clinical infection. A killed-virus vaccine has been developed, which is in Phase III clinical trials. Analyses of intra-host genetic diversity and of long-term evolutionary changes in Ross River virus populations suggest that antigenic variation is unlikely to pose a threat to the efficacy of this vaccine.

Impact and interest:

3 citations in Scopus
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2 citations in Web of Science®

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ID Code: 63289
Item Type: Journal Article
Refereed: Yes
Keywords: Ross River virus, Vaccine, Mosquito-borne alphavirus
DOI: 10.2217/fvl.11.139
ISSN: 1746-0808
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 14 Oct 2013 03:47
Last Modified: 30 Jun 2014 02:54

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