A poly(lactic-co-glycolic acid) knitted scaffold for tendon tissue engineering: an in vitro and in vivo study

Vaquette, Cedryck, Slimani, Said, Kahn, Cyril J.F., Tran, Nguyen, Rahouadj, Rachid, & Wang, Xiong (2010) A poly(lactic-co-glycolic acid) knitted scaffold for tendon tissue engineering: an in vitro and in vivo study. Journal of Biomaterial Science: Polymer Edition, 21(13), pp. 1737-1760.

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Abstract

We have designed a composite scaffold for potential use in tendon or ligament tissue engineering. The composite scaffold was made of a cellularized alginate gel that encapsulated a knitted structure. Our hypothesis was that the alginate would act as a cell carrier and deliver cells to the injury site while the knitted structure would provide mechanical strength to the composite construct. The mechanical behaviour and the degradation profile of the poly(lactic-co-glycolic acid) knitted scaffolds were evaluated. We found that our scaffolds had an elastic modulus of 750 MPa and that they lost their physical integrity within 7 weeks of in vitro incubation. Autologous rabbit mesenchymal stem cell seeded composite scaffolds were implanted in a 1-cm-long defect created in the rabbit tendon, and the biomechanical properties and the morphology of the regenerated tissues were evaluated after 13 weeks. The regenerated tendons presented higher normalized elastic modulus of (60%) when compared with naturally healed tendons (40%). The histological study showed a higher cell density and vascularization in the regenerated tendons.

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20 citations in Scopus
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16 citations in Web of Science®

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ID Code: 63338
Item Type: Journal Article
Refereed: Yes
Keywords: Tissue engineering, composite scaffold, knitted scaffold, degradation, alginate
DOI: 10.1163/092050609X12560455246676
ISSN: 0920-5063
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 15 Oct 2013 01:58
Last Modified: 22 Nov 2013 05:09

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