Increasing electrospun scaffold pore size with tailored collectors for improved cell penetration

Vaquette, Cedryck & Cooper-White, Justin (2011) Increasing electrospun scaffold pore size with tailored collectors for improved cell penetration. Acta Biomaterialia, 7(6), pp. 2544-2557.

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Abstract

This study investigates the use of patterned collectors to increase the pore size of electrospun scaffolds for enhanced cell infiltration. The morphology of the patterned scaffolds was investigated by scanning electron microscopy, which showed that the collector pattern was accurately mimicked by the electrospun fibres. We observed an enlargement in the pore size and in the pore size distribution compared with conventional electrospinning. Mechanical testing revealed that the mechanical properties could be tailored, to some extent, according to the patterning and that the patterned scaffolds were softer than standard electrospun scaffolds. When NIH 3T3 fibroblasts were seeded onto patterned collectors improved cell infiltration was observed. Cells were able to penetrate up to 250 μm into the scaffolds, compared with 30 μm for the standard scaffolds. This increase in the depth of infiltration occurred as early as 24 h post-seeding and remained constant over 7 days.

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ID Code: 63353
Item Type: Journal Article
Refereed: Yes
Keywords: Electrospinning; Patterned collectors; Pore size; Cell penetration; Polycaprolactone
DOI: 10.1016/j.actbio.2011.02.036
ISSN: 1742-7061
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Crown Copyright 2011 Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
Deposited On: 15 Oct 2013 00:23
Last Modified: 25 Nov 2013 03:00

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