Natural, engineered and synthetic inhibitors of kallikrein-related peptidases

Swedberg, Joakim E., Veer, Simon J. De, & Harris, Jonathan M. (2012) Natural, engineered and synthetic inhibitors of kallikrein-related peptidases. In Magdolen, V., Sommerhoff, C.P., Fritz, H., & Schmitt, M. (Eds.) Kallikrein-Related Peptidases - Volume 1 : Characterization, regulation, and interactions within the protease web. Walter de Gruyter GmbH, Berlin, pp. 141-160.

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There is a rapidly growing appreciation of the important physiological roles played by kallikreins and kallikrein-related peptidases (KLKs). Recent studies have revealed that these enzymes control key events in processes as diverse as inflammation and skin desquamation. Accordingly, there is considerable interest in developing tools to further dissect kallikrein activity, and a burgeoning effort aimed at producing lead inhibitors for therapeutic development. Indeed, several candidate inhibitors are already in clinical trials. This chapter surveys the naturally occurring kallikrein inhibitors, together with strategies for employing these molecules as bioscaffolds, as well as current progress in the development of small-molecule kallikrein inhibitors.

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ID Code: 63449
Item Type: Book Chapter
Keywords: Kallikrein, Enzymes, Proteases
DOI: 10.1515/9783110260373.141
ISBN: 9783110260373
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Enzymes (060107)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genomics (060408)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Walter de Gruyter GmbH
Deposited On: 17 Oct 2013 23:38
Last Modified: 30 Oct 2013 04:27

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