Clinical outcomes of vitamin D deficiency and supplementation in cancer patients
Teleni, Laisa, Baker, Jacqueline, Koczwara, Bogda, Kimlin, Michael G., Walpole, Euan, Tsai, Kathy, & Isenring, Elisabeth A. (2013) Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. Nutrition Reviews, 71(9), pp. 611-621.
Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes. The present systematic review was undertaken to determine the prevalence of vitamin D deficiency (<25 nmol/L) and insufficiency (25-50 nmol/L) in cancer patients and to evaluate the association between circulating calcidiol (the indicator of vitamin D status) and clinical outcomes. A systematic search of original, peer-reviewed studies on calcidiol at cancer diagnosis, and throughout treatment and survival, was conducted yielding 4,706 studies. A total of 37 studies met the inclusion criteria for this review. Reported mean blood calcidiol levels ranged from 24.7 to 87.4 nmol/L, with up to 31% of patients identified as deficient and 67% as insufficient. The efficacy of cholecalciferol supplementation for raising the concentration of circulating calcidiol is unclear; standard supplement regimens of <1,000 IU D3 /day may not be sufficient to maintain adequate concentrations or prevent decreasing calcidiol. Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking.
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|Item Type:||Journal Article|
|Keywords:||25-hydroxyvitamin D, cancer, cancer-specific outcomes, cholecalciferol, vitamin D deficiency|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
|Deposited On:||21 Oct 2013 23:54|
|Last Modified:||22 Oct 2013 23:02|
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