Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females

Morrison, Nigel A., Stephens, Alexandre S., Osato, Motomi, Pasco, Julie A., Fozzard, Nicolette, Stein, Gary S., Polly, Patsie, Griffiths, Lyn R., & Nicholson, Geoff C. (2013) Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females. Public Library of Science, 8(9), e72740.

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Abstract

Runt related transcription factor 2 (RUNX2) is a key regulator of osteoblast differentiation. Several variations within RUNX2 have been found to be associated with significant changes in BMD, which is a major risk factor for fracture. In this study we report that an 18bp deletion within the polyalanine tract (17A>11A) of RUNX2 is significantly associated with fracture. Carriers of the 11A allele were found to be nearly twice as likely to have sustained fracture. Within the fracture category, there was a significant tendency of 11A carriers to present with fractures of bones of intramembranous origin compared to bones of endochondral origin (p=0.005). In a population of random subjects, the 11A allele was associated with decreased levels of serum collagen cross links (CTx, p=0.01), suggesting decreased bone turnover. The transactivation function of the 11A allele was quantitatively decreased. Interestingly, we found no effect of the 11A allele on BMD at multiple skeletal sites, although these were not the sites where a relationship with fracture was most evident. These findings suggest that the 11A allele is a biologically relevant polymorphism that influences serum CTx and confers enhanced fracture risk in a site-selective manner related to intramembranous bone ossification.

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ID Code: 63713
Item Type: Journal Article
Refereed: Yes
DOI: 10.1371/journal.pone.0072740
ISSN: 1932-6203
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 the authors
Deposited On: 25 Oct 2013 00:44
Last Modified: 12 Nov 2013 02:06

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