Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography

Alonso-Caneiro, D., Yamanari, M., Fukuda, S., Hoshi , S., Nagase, S., Oshika, T., Yasuno, Y., & Collins, M.J. (2013) Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography. In SPIE Proceedings, Ophthalmic Technologies XXIII, San Francisco, California, 85670F-1.

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Collagen crosslinking (CXL) has shown promising results in the prevention of the progression of keratoconus and corneal ectasia. However, techniques for in vivo and in situ assessment of the treatment are limited. In this study, ex vivo porcine eyes were treated with a chemical CXL agent (glutaraldehyde), during which polarization sensitive optical coherence tomography (PS-OCT) recordings were acquired simultaneously to assess the sensitivity of the technique to assess changes in the cornea. The results obtained in this study suggest that PS-OCT may be a suitable technique to measure CXL changes in situ and to assess the local changes in the treated region of the cornea.

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ID Code: 63734
Item Type: Conference Paper
Refereed: Yes
Keywords: cross-linking, OCT, polarization sensitive, biomechanics
DOI: 10.1117/12.2002988
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomedical Instrumentation (090303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optometry and Ophthalmology not elsewhere classified (111399)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2013 SPIE
Deposited On: 28 Oct 2013 01:32
Last Modified: 30 Oct 2013 04:47

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