Dengue fever viral exposure rates among blood donors during outbreaks in North Queensland

Fryk, Jesse, Faddy, Helen, McBride, John, Ritchie, Scott, Hyland , Catherine, Flower, Robert L. P., & Christensen, Anne-Marie (2010) Dengue fever viral exposure rates among blood donors during outbreaks in North Queensland. Australian Journal of Medical Science, 31(4), p. 165.


Introduction: Dengue poses a problem for safe transfusion of blood components with confirmed reports of transfusion-transmission in Hong Kong and Singapore. The largest outbreak in 50 years occurred in North Queensland during 2008/2009 with more than 1,000 confirmed cases in Cairns and Townsville. During this outbreak, supplementary questioning for all donors was implemented, and fresh components were not manufactured from at risk donors. We aim to determine the seroprevalence of dengue exposure in this population during this epidemic.

Methods: Samples were collected from blood donors during the 2008/2009 epidemic and 3 months after the last confirmed case. These samples were tested for anti-Dengue IgM, IgG and NS1 antigen with commercially available ELISA based assay kits from PanBio.

Results: Initial analyses revealed 2.7% of samples from deferred donors were IgM repeat reactive. Of these, 16% were also positive for anti-dengue IgG, while none of these were positive for the NS1 viral antigen. However, two NS1 positives were found in samples collected from deferred donors.

Conclusions: This initial analysis represents recent and cumulative past exposure in a presumed asymptomatic population, and will provide documentation of the rate of asymptomatic dengue infection during the epidemic. This data can also be used to assess the risk of dengue becoming endemic in North Queensland given that the mosquito vector is established in this region.

Impact and interest:

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ID Code: 63748
Item Type: Journal Article
Refereed: Yes
Additional Information: AIMS AACB NSM 2010 Abstracts
Additional URLs:
Keywords: Dengue, Transfusion, Seroprevalence
ISSN: 1038-1643
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 28 Oct 2013 04:31
Last Modified: 30 Oct 2013 02:24

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