MS-based metabolomics facilitates the discovery of in vivo functional small molecules with a diversity of biological contexts
Yan, Leyu, Nie, Wenna, Parker, Tony, Upton, Zee, & Lu, Haitao (2013) MS-based metabolomics facilitates the discovery of in vivo functional small molecules with a diversity of biological contexts. Future medicinal chemistry, 5(16), pp. 1953-1965.
In vivo small molecules as necessary intermediates are involved in numerous critical metabolic pathways and biological processes associated with many essential biological functions and events. There is growing evidence that MS-based metabolomics is emerging as a powerful tool to facilitate the discovery of functional small molecules that can better our understanding of development, infection, nutrition, disease, toxicity, drug therapeutics, gene modifications and host-pathogen interaction from metabolic perspectives. However, further progress must still be made in MS-based metabolomics because of the shortcomings in the current technologies and knowledge. This technique-driven review aims to explore the discovery of in vivo functional small molecules facilitated by MS-based metabolomics and to highlight the analytic capabilities and promising applications of this discovery strategy. Moreover, the biological significance of the discovery of in vivo functional small molecules with different biological contexts is also interrogated at a metabolic perspective.
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|Item Type:||Journal Article|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||03 Nov 2013 22:16|
|Last Modified:||28 Jan 2014 00:55|
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