Spectroscopic correlation analysis of NMR-based metabonomics in exercise science

Kirwan, Gemma M., Coffey, Vernon G., Niere, Julie O. , Hawley, John A., & Adams, Michael J. (2009) Spectroscopic correlation analysis of NMR-based metabonomics in exercise science. Analytica Chimica Acta, 652(1-2), pp. 173-179.

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Spectroscopic studies of complex clinical fluids have led to the application of a more holistic approach to their chemical analysis becoming more popular and widely employed. The efficient and effective interpretation of multidimensional spectroscopic data relies on many chemometric techniques and one such group of tools is represented by so-called correlation analysis methods. Typical of these techniques are two-dimensional correlation analysis and statistical total correlation spectroscopy (STOCSY). Whilst the former has largely been applied to optical spectroscopic analysis, STOCSY was developed and has been applied almost exclusively to NMR metabonomic studies. Using a 1H NMR study of human blood plasma, from subjects recovering from exhaustive exercise trials, the basic concepts and applications of these techniques are examined. Typical information from their application to NMR-based metabonomics is presented and their value in aiding interpretation of NMR data obtained from biological systems is illustrated. Major energy metabolites are identified in the NMR spectra and the dynamics of their appearance and removal from plasma during exercise recovery are illustrated and discussed. The complementary nature of two-dimensional correlation analysis and statistical total correlation spectroscopy are highlighted.

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ID Code: 64141
Item Type: Journal Article
Refereed: Yes
Keywords: Nuclear magnetic resonance, Metabonomics, Correlation spectroscopy, Statistical total correlation spectroscopy, Covariance matrix, Chemometrics
DOI: 10.1016/j.aca.2009.07.011
ISSN: 0003-2670
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 08 Nov 2013 00:17
Last Modified: 13 Nov 2013 03:40

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