mTOR function in skeletal muscle : a focal point for overnutrition and exercise

Rivas, Donato A., Lessard, Sarah J., & Coffey, Vernon G. (2009) mTOR function in skeletal muscle : a focal point for overnutrition and exercise. Applied Physiology, Nutrition and Metabolism, 34(5), pp. 807-816.

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Abstract

The mammalian target of rapamycin (mTOR) is a highly conserved atypical serine-threonine kinase that controls numerous functions essential for cell homeostasis and adaptation in mammalian cells via 2 distinct protein complex formations. Moreover, mTOR is a key regulatory protein in the insulin signalling cascade and has also been characterized as an insulin-independent nutrient sensor that may represent a critical mediator in obesity-related impairments of insulin action in skeletal muscle. Exercise characterizes a remedial modality that enhances mTOR activity and subsequently promotes beneficial metabolic adaptation in skeletal muscle. Thus, the metabolic effects of nutrients and exercise have the capacity to converge at the mTOR protein complexes and subsequently modify mTOR function. Accordingly, the aim of the present review is to highlight the role of mTOR in the regulation of insulin action in response to overnutrition and the capacity for exercise to enhance mTOR activity in skeletal muscle.

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ID Code: 64142
Item Type: Journal Article
Refereed: Yes
Keywords: nutrients, insulin action, metabolism, training
DOI: 10.1139/H09-073
ISSN: 1715-5312
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NUTRITION AND DIETETICS (111100) > Clinical and Sports Nutrition (111101)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 08 Nov 2013 00:11
Last Modified: 13 Nov 2013 04:06

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