Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle

Coffey, Vernon G., Reeder, Donald W., Lancaster, Graeme I., Yeo, Wee Kian, Febbraio, Mark A., Yaspelkis III, Benjamin B., & Hawley, John A. (2007) Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle. Medicine & Science in Sports & Exercise, 39(12), pp. 2135-2144.

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Abstract

PURPOSE: Regulation of skeletal muscle mass is highly dependent on contractile loading. The purpose of this study was to examine changes in growth factor and inflammatory pathways following high-frequency resistance training.

METHODS: Using a novel design in which male Sprague-Dawley rats undertook a "stacked" resistance training protocol designed to generate a summation of transient exercise-induced signaling responses (four bouts of three sets × 10 repetitions of squat exercise, separated by 3 h of recovery), we determined the effects of high training frequency on signaling pathways and transcriptional activity regulating muscle mass.

RESULTS: The stacked training regimen resulted in acute suppression of insulin-like growth factor 1 mRNA abundance (P < 0.05) and Akt phosphorylation (P < 0.05), an effect that persisted 48 h after the final training bout. Conversely, stacked training elicited a coordinated increase in the expression of tumor necrosis factor alpha, inhibitor kappa B kinase alpha/beta activity (P < 0.05), and p38 mitogen-activated protein kinase phosphorylation (P < 0.05) at 3 h after each training bout. In addition, the stacked series of resistance exercise bouts induced an increase in p70 S6 kinase phosphorylation 3 h after bouts ×3 and ×4, independent of the phosphorylation state of Akt.

CONCLUSIONS: Our results indicate that high resistance training frequency extends the transient activation of inflammatory signaling cascades, concomitant with persistent suppression of key mediators of anabolic responses. We provide novel insights into the effects of the timing of exercise-induced overload and recovery on signal transduction pathways and transcriptional activity regulating skeletal muscle mass in vivo.

Impact and interest:

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16 citations in Web of Science®

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ID Code: 64147
Item Type: Journal Article
Refereed: Yes
Keywords: CELL SIGNALING, mRNA, RESISTANCE TRAINING, RECOVERY
DOI: 10.1249/mss.0b013e31815729b6
ISSN: 0195-9131
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 07 Nov 2013 23:26
Last Modified: 13 Nov 2013 05:18

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