The structure of Pavlovian fear conditioning in the amygdala

Bergstrom, Hadley C., McDonald, Craig G., Dey, Smita, Tang, Haying, Selwyn, Reed G., & Johnson, Luke R. (2012) The structure of Pavlovian fear conditioning in the amygdala. Brain Structure and Function, 218(6), pp. 1569-1589.

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Abstract

Do different brains forming a specific memory allocate the same groups of neurons to encode it? One way to test this question is to map neurons encoding the same memory and quantitatively compare their locations across individual brains. In a previous study, we used this strategy to uncover a common topography of neurons in the dorsolateral amygdala (LAd) that expressed a learning-induced and plasticity-related kinase (p42/44 mitogen-activated protein kinase; pMAPK), following auditory Pavlovian fear conditioning. In this series of experiments, we extend our initial findings to ask to what extent this functional topography depends upon intrinsic neuronal structure. We first showed that the majority (87 %) of pMAPK expression in the lateral amygdala was restricted to principal-type neurons. Next, we verified a neuroanatomical reference point for amygdala alignment using in vivo magnetic resonance imaging and in vitro morphometrics. We then determined that the topography of neurons encoding auditory fear conditioning was not exclusively governed by principal neuron cytoarchitecture. These data suggest that functional patterning of neurons undergoing plasticity in the amygdala following Pavlovian fear conditioning is specific to memory formation itself. Further, the spatial allocation of activated neurons in the LAd was specific to cued (auditory), but not contextual, fear conditioning. Spatial analyses conducted at another coronal plane revealed another spatial map unique to fear conditioning, providing additional evidence that the functional topography of fear memory storing cells in the LAd is non-random and stable. Overall, these data provide evidence for a spatial organizing principle governing the functional allocation of fear memory in the amygdala.

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ID Code: 64167
Item Type: Journal Article
Refereed: Yes
Keywords: Basal amygdala; Calcium calmodulin-dependent protein kinase II (CAMKII); Consolidation; Cytoarchitecture; Dual-labeling immunofluorescence; Fear; Fear learning; Lateral amygdala; Lateral ventricle; Magnetic resonance imaging (MRI); Mapping; Memory; Micro
DOI: 10.1007/s00429-012-0478-2
ISSN: 1863-2661
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Copyright Owner: Elsevier
Deposited On: 07 Nov 2013 10:36
Last Modified: 22 Nov 2013 01:23

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