Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear

Choi, Kwang, Le, Thien, McGuire, Jennifer, Xing, Guoqiang, Zhang, Lei, Li, He, Parker, Clarissa C., Johnson, Luke R., & Ursano, Robert J. (2012) Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear. Journal of Psychiatric Research, 46(7), pp. 882-889.

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Although the endocannabinoid system (ECS) has been implicated in brain development and various psychiatric disorders, precise mechanisms of the ECS on mood and anxiety disorders remain unclear. Here, we have investigated developmental and disease-related expression pattern of the cannabinoid receptor 1 (CB1) and the cannabinoid receptor 2 (CB2) genes in the dorsolateral prefrontal cortex (PFC) of humans. Using mice selectively bred for high and low fear, we further investigated potential association between fear memory and the cannabinoid receptor expression in the brain. The CB1, not the CB2, mRNA levels in the PFC gradually decrease during postnatal development ranging in age from birth to 50 years (r 2 > 0.6 & adj. p < 0.05). The CB1 levels in the PFC of major depression patients were higher when compared to the age-matched controls (adj. p < 0.05). In mice, the CB1, not the CB2, levels in the PFC were positively correlated with freezing behavior in classical fear conditioning (p < 0.05). These results suggest that the CB1 in the PFC may play a significant role in regulating mood and anxiety symptoms. Our study demonstrates the advantage of utilizing data from postmortem brain tissue and a mouse model of fear to enhance our understanding of the role of the cannabinoid receptors in mood and anxiety disorders

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25 citations in Scopus
18 citations in Web of Science®
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ID Code: 64170
Item Type: Journal Article
Refereed: Yes
Keywords: Anxiety disorder; Childhood trauma; Endocannabinoid system; Fear extinction; Fear learning; Major depressive disorder; Posttraumatic stress disorder
DOI: 10.1016/j.jpsychires.2012.03.021
ISSN: 00223956
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Copyright Owner: Elsevier
Deposited On: 07 Nov 2013 12:02
Last Modified: 30 Jun 2014 02:53

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