Pavlovian fear memory circuits and phenotype models of PTSD

Johnson, Luke R., McGuire, Jennifer, Lazarus, Rachel, & Palmer, Abraham A. (2012) Pavlovian fear memory circuits and phenotype models of PTSD. Neuropharmacology, 62(2), pp. 638-646.

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Abstract

Pavlovian fear conditioning, also known as classical fear conditioning is an important model in the study of the neurobiology of normal and pathological fear. Progress in the neurobiology of Pavlovian fear also enhances our understanding of disorders such as posttraumatic stress disorder (PTSD) and with developing effective treatment strategies. Here we describe how Pavlovian fear conditioning is a key tool for understanding both the neurobiology of fear and the mechanisms underlying variations in fear memory strength observed across different phenotypes. First we discuss how Pavlovian fear models aspects of PTSD. Second, we describe the neural circuits of Pavlovian fear and the molecular mechanisms within these circuits that regulate fear memory. Finally, we show how fear memory strength is heritable; and describe genes which are specifically linked to both changes in Pavlovian fear behavior and to its underlying neural circuitry. These emerging data begin to define the essential genes, cells and circuits that contribute to normal and pathological fear.

Impact and interest:

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ID Code: 64171
Item Type: Journal Article
Refereed: Yes
Keywords: Amygdala; Classical conditioning; Hippocampus; Micro anatomy; Post traumatic stress disorder; QTL
DOI: 10.1016/j.neuropharm.2011.07.004
ISSN: 00283908
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Deposited On: 07 Nov 2013 11:59
Last Modified: 22 Nov 2013 01:44

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