Analysis of kinase gene expression in the frontal cortex of suicide victims: Implications of fear and stress

Ursano, Robert J., Johnson, Luke R., Xing, Guoqiang, Le, Thien, & Choi, Kwang (2011) Analysis of kinase gene expression in the frontal cortex of suicide victims: Implications of fear and stress. Frontiers in Behavioral Neuroscience, 5(July).

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Abstract

Suicide is a serious public health issue that results from an interaction between multiple risk factors including individual vulnerabilities to complex feelings of hopelessness, fear, and stress. Although kinase genes have been implicated in fear and stress, including the consolidation and extinction of fearful memories, expression profiles of those genes in the brain of suicide victims are less clear. Using gene expression microarray data from the Online Stanley Genomics Database 1 and a quantitative PCR, we investigated the expression profiles of multiple kinase genes including the calcium calmodulin-dependent kinase (CAMK), the cyclin-dependent kinase, the mitogen-activated protein kinase (MAPK), and the protein kinase C (PKC) in the prefrontal cortex (PFC) of mood disorder patients died with suicide (N = 45) and without suicide (N = 38). We also investigated the expression pattern of the same genes in the PFC of developing humans ranging in age from birth to 49 year (N = 46). The expression levels of CAMK2B, CDK5, MAPK9, and PRKCI were increased in the PFC of suicide victims as compared to non-suicide controls (false discovery rate, FDR-adjusted p < 0.05, fold change >1.1). Those genes also showed changes in expression pattern during the postnatal development (FDR-adjusted p < 0.05). These results suggest that multiple kinase genes undergo age-dependent changes in normal brains as well as pathological changes in suicide brains. These findings may provide an important link to protein kinases known to be important for the development of fear memory, stress associated neural plasticity, and up-regulation in the PFC of suicide victims. More research is needed to better understand the functional role of these kinase genes that may be associated with the pathophysiology of suicide

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ID Code: 64173
Item Type: Journal Article
Refereed: Yes
Keywords: brain development, frontal cortex, posttraumatic stress disorder, anxiety disorder, psychiatric genomics, bioinformatics
DOI: 10.3389/fnbeh.2011.00046
ISSN: 1662-5153
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Copyright Owner: © 2011 Choi, Le, Xing, Johnson and Ursano
Copyright Statement: This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
Deposited On: 07 Nov 2013 11:46
Last Modified: 22 Nov 2013 02:32

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