Electrochemical detection of dopamine and cytochrome c at a nanostructured gold electrode

Plowman, Blake J, Mahajan, Manika, O'Mullane, Anthony P, & Bhargava, Suresh K (2010) Electrochemical detection of dopamine and cytochrome c at a nanostructured gold electrode. Electrochimica Acta, 55(28), pp. 8953-8959.

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Abstract

A nanostructured gold surface consisting of closely packed outwardly growing spikes is investigated for the electrochemical detection of dopamine and cytochrome c. A significant electrocatalytic effect for the electrooxidation of both dopamine and ascorbic acid at the nanostructured electrode was found due to the presence of surface active sites which allowed the detection of dopamine in the presence of excess ascorbic acid to be achieved by differential pulse voltammetry. By simple modification with a layer of Nafion, the enhanced electrocatalytic properties of the nanostructured surface was maintained while increasing the selectivity of dopamine detection in the presence of interfering species such as excess ascorbic and uric acids. Also, upon modification of the nanostructured surface with a monolayer of cysteine, the electrochemical response of immobilised cytochrome c in two distinct conformations was observed. This opens up the possibility of using such a nanostructured surface for the characterisation of other biomolecules and in bio-electroanalytical applications.

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ID Code: 64286
Item Type: Journal Article
Refereed: Yes
Keywords: Nanostructured gold; Dopamine; Cytochrome c; Voltammetry
DOI: 10.1016/j.electacta.2010.08.045
ISSN: 0013-4686
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 12 Nov 2013 05:01
Last Modified: 19 Nov 2013 01:11

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