Ginger - mechanism of action in chemotherapy-induced nausea and vomiting: A review

Marx, Wolfgang M., Ried, Karin, McCarthy, Alexandra L., Vitetta, Luis, Sali, Avni, McKavanagh, Dan, & Isenring, Liz (2017) Ginger - mechanism of action in chemotherapy-induced nausea and vomiting: A review. Critical Reviews in Food Science and Nutrition, 57(1), pp. 141-146.

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Despite advances in anti-emetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT3, substance P and acetylcholine receptor antagonism; anti-inflammatory properties; and modulation of cellular redox signalling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing chemotherapy-induced nausea and vomiting.

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ID Code: 64534
Item Type: Journal Article
Refereed: Yes
Additional Information: Accepted author version posted online: 07 Apr 2015, Published online: 07 Apr 2015
Additional URLs:
Keywords: ginger, nausea, chemotherapy, CINV, vomiting
DOI: 10.1080/10408398.2013.865590
ISSN: 1040-8398
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Copyright Owner: Copyright 2013 Taylor & Francis Group
Deposited On: 17 Nov 2013 23:20
Last Modified: 26 Oct 2016 00:35

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