Application of texture analysis in tear film surface assessment based on videokeratoscopy

Alonso-Caneiro, David, Szczesna-Iskander, Dorota H., Iskander, D. Robert, Read, Scott A., & Collins, Michael J. (2013) Application of texture analysis in tear film surface assessment based on videokeratoscopy. Journal of Optometry, 6(4), pp. 185-193.

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Purpose Videokeratoscopy images can be used for the non-invasive assessment of the tear film. In this work the applicability of an image processing technique, textural-analysis, for the assessment of the tear film in Placido disc images has been investigated.

Methods In the presence of tear film thinning/break-up, the reflected pattern from the videokeratoscope is disturbed in the region of tear film disruption. Thus, the Placido pattern carries information about the stability of the underlying tear film. By characterizing the pattern regularity, the tear film quality can be inferred. In this paper, a textural features approach is used to process the Placido images. This method provides a set of texture features from which an estimate of the tear film quality can be obtained. The method is tested for the detection of dry eye in a retrospective dataset from 34 subjects (22-normal and 12-dry eye), with measurements taken under suppressed blinking conditions.

Results To assess the capability of each texture-feature to discriminate dry eye from normal subjects, the receiver operating curve (ROC) was calculated and the area under the curve (AUC), specificity and sensitivity extracted. For the different features examined, the AUC value ranged from 0.77 to 0.82, while the sensitivity typically showed values above 0.9 and the specificity showed values around 0.6. Overall, the estimated ROCs indicate that the proposed technique provides good discrimination performance.

Conclusions Texture analysis of videokeratoscopy images is applicable to study tear film anomalies in dry eye subjects. The proposed technique appears to have demonstrated its clinical relevance and utility.

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ID Code: 64567
Item Type: Journal Article
Refereed: Yes
Keywords: Image processing, tear film, dry eye, texture analysis
DOI: 10.1016/j.optom.2013.07.006
ISSN: 1888-4296
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optometry and Ophthalmology not elsewhere classified (111399)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2013 Spanish General Council of Optometry. Published by Elsevier España, S.L.
Copyright Statement: NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Optometry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Optometry, [Volume 6, Issue 4, (October–December 2013)] DOI: 10.1016/j.optom.2013.07.006
Deposited On: 17 Nov 2013 22:52
Last Modified: 03 Nov 2014 21:53

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