Booster vaccination of toddlers with reduced antigen content diphtheria-tetanus-acellular pertussis vaccine

Nolan, Terry, Ruff, Tilman A., Lambert, Stephen B., Buttery, Jim, O'Grady, Kerry-Ann, Streeton, Catherine, Hoet, Bernard, & Bock, Hans L. (2009) Booster vaccination of toddlers with reduced antigen content diphtheria-tetanus-acellular pertussis vaccine. Vaccine, 27(18), pp. 2410-2413.

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Abstract

Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18-20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and >= 93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016 IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given. (C) 2009 Elsevier Ltd. All rights reserved.

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2 citations in Web of Science®

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ID Code: 64700
Item Type: Journal Article
Refereed: Yes
Additional Information: 432ZN--
Times Cited:2--
Cited References Count:17--http://WOS:000265173100002
Keywords: acellular pertussis vaccine, booster, vaccination, polio vaccine, immunogenicity, children, reactogenicity, combination, infancy, safety, life, age
DOI: 10.1016/j.vaccine.2009.02.065
ISSN: 0264-410X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 26 Nov 2013 02:47
Last Modified: 27 Nov 2013 03:26

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