The epidemiology of invasive group A streptococcal disease in Victoria, Australia
O'Grady, Kerry-Ann, Kelpie, Loraine, Andrews, Ross M., Curtis, Nigel, Nolan, Terence M., Selvaraj, Gowri, Passmore, Jonathon W., Oppedisano, Frances, Carnie, John A., & Carapetis, Jonathan R. (2007) The epidemiology of invasive group A streptococcal disease in Victoria, Australia. Medical Journal of Australia, 186(11), pp. 565-569.
To estimate the incidence and severity of invasive group A streptococcal infection in Victoria, Australia.
Prospective active surveillance study.
Public and private laboratories, hospitals and general practitioners throughout Victoria.
eople in Victoria diagnosed with group A streptococcal disease notified to the surveillance system between 1 March 2002 and 31 August 2004.
Main outcome measure
Confirmed invasive group A streptococcal disease.
We identified 333 confirmed cases: an average annualised incidence rate of 2.7 (95% CI, 2.3-3.2) per 100000 population per year. Rates were highest in people aged 65 years and older and those younger than 5 years. The case-fatality rate was 7.8%. Streptococcal toxic shock syndrome occurred in 48 patients (14.4%), with a case-fatality rate of 23%. Thirty cases of necrotising fasciitis were reported; five (17%) of these patients died. Type 1 (23%) was the most frequently identified emm sequence type in all, age groups. All tested isolates were susceptible to penicillin and clindamycin. Two isolates (4%) were resistant to erythromycin.
The incidence of invasive group A streptococcal disease in temperate Australia is greater than previously appreciated and warrants greater public health attention, including its designation as a notifiable disease.
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|Item Type:||Journal Article|
Cited References Count:38--
|Keywords:||toxic-shock-syndrome, health-care workers, m-protein, infections, vaccine, immunoglobulin, bacteremia, management, therapy, antibodies|
|Subjects:||Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Deposited On:||26 Nov 2013 01:15|
|Last Modified:||09 Apr 2014 12:22|
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