Surgical resection for non-small cell lung cancer : clinical features and outcomes for a consecutive series at an Irish tertiary referral centre

Al-Alao, B. S., O'Callaghan, D. S., Gately, K., Nicholson, S., Coate, L. E., O'Connell, F., McGovern, E., O'Byrne, Kenneth J., & Young, V. K. (2013) Surgical resection for non-small cell lung cancer : clinical features and outcomes for a consecutive series at an Irish tertiary referral centre. Irish Journal of Medical Science, 182(2), pp. 217-225.

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Background: Few patients diagnosed with lung cancer are still alive 5 years after diagnosis. The aim of the current study was to conduct a 10-year review of a consecutive series of patients undergoing curative-intent surgical resection at the largest tertiary referral centre to identify prognostic factors.

Methods: Case records of all patients operated on for lung cancer between 1998 and 2008 were reviewed. The clinical features and outcomes of all patients with non-small cell lung cancer (NSCLC) stage I-IV were recorded. Results: A total of 654 patients underwent surgical resection with curative intent during the study period. Median overall survival for the entire cohort was 37 months. The median age at operation was 66 years, with males accounting for 62.7 %. Squamous cell type was the most common histological subtype, and lobectomies were performed in 76.5 % of surgical resections. Pneumonectomy rates decreased significantly in the latter half of the study (25 vs. 16.3 %), while sub-anatomical resection more than doubled (2 vs. 5 %) (p < 0.005). Clinico-pathological characteristics associated with improved survival by univariate analysis include younger age, female sex, smaller tumour size, smoking status, lobectomy, lower T and N status and less advanced pathological stage. Age, gender, smoking status and tumour size, as well as T and N descriptors have emerged as independent prognostic factors by multivariate analysis.

Conclusion: We identified several factors that predicted outcome for NSCLC patients undergoing curative-intent surgical resection. Survival rates in our series are comparable to those reported from other thoracic surgery centres. © 2012 Royal Academy of Medicine in Ireland.

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ID Code: 64775
Item Type: Journal Article
Refereed: Yes
Keywords: Non-small cell lung cancer, Outcome, Prognostic factors and prognosis, Surgery, Survival, adult, age, aged, article, cancer prognosis, cancer surgery, cancer survival, clinical feature, cohort analysis, disease severity, female, human, lobectomy, lung lobectomy, lung non small cell cancer, lung resection, lung squamous cell carcinoma, major clinical study, male, medical record review, overall survival, sex difference, smoking, tertiary health care, treatment outcome, tumor volume, Ireland, Kaplan Meier method, lung tumor, middle aged, mortality, pathology, patient referral, prognosis, survival rate, thorax surgery, very elderly, Age Factors, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Humans, Kaplan-Meier Estimate, Lung Neoplasms, Pneumonectomy, Referral and Consultation, Sex Factors, Thoracic Surgical Procedures
DOI: 10.1007/s11845-012-0863-0
ISSN: 0021-1265
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Springer UK
Deposited On: 25 Nov 2013 03:01
Last Modified: 26 Nov 2013 00:12

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