Bone matters in lung cancer

Brodowicz, T., O'Byrne, Kenneth J., & Manegold, C. (2012) Bone matters in lung cancer. Annals of Oncology, 23(9), pp. 2215-2222.

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Abstract

Background: Bone metastases are a significant and undertreated clinical problem in patients with advanced lung cancer.

Design: We reviewed the incidence of bone metastases and skeletal-related events (SREs) in patients with lung cancer and examined the burden on patients' lives and on health care systems. Available therapies to improve survival and lessen the impact of SREs on quality of life (QoL) were also investigated.

Results: Bone metastases are common in lung cancer; however, owing to short survival times, data on the incidences of SREs are limited. As with other cancers, the costs associated with treating SREs in lung cancer are substantial. Bisphosphonates reduce the frequency of SREs and improve measures of pain and QoL in patients with lung cancer; however, nephrotoxicity is a common complication of therapy. Denosumab, a recently approved bone-targeted therapy, is superior to zoledronic acid in increasing the time to first on-study SRE in patients with solid tumours, including lung cancer. Additional roles of bone-targeted therapies beyond the prevention of SREs are under investigation.

Conclusions: With increasing awareness of the consequences of SREs, bone-targeted therapies may play a greater role in the management of patients with lung cancer, with the aim of delaying disease progression and preserving QoL. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology.

Impact and interest:

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11 citations in Web of Science®

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ID Code: 64848
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
Additional URLs:
Keywords: Bone metastases, Lung neoplasms, Neoplasm metastases, Quality of life, Skeletal-related events, bevacizumab, bisphosphonic acid derivative, carboplatin, cisplatin, denosumab, gefitinib, mitomycin C, placebo, vinblastine, zoledronic acid, bone metastasis, bone pain, bone scintiscanning, cancer survival, drug efficacy, drug megadose, drug response, drug targeting, gastrointestinal toxicity, health care cost, human, jaw osteonecrosis, lung cancer, lung non small cell cancer, nephrotoxicity, nonhuman, pain assessment, priority journal, review, solid tumor, spinal cord metastasis, survival time, treatment outcome, Animals, Bone Neoplasms, Carcinoma, Non-Small-Cell Lung, Clinical Trials as Topic, Health Care Costs, Humans, Molecular Targeted Therapy, Pain Management
DOI: 10.1093/annonc/mds009
ISSN: 0923-7534
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Oxford University Press
Deposited On: 27 Nov 2013 06:22
Last Modified: 27 Jan 2015 05:10

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