Chemotherapy induced reversible posterior leukoencephalopathy syndrome

Connolly, Roisin M., Doherty, Colin P., Beddy, Peter, & O'Byrne, Kenneth J. (2007) Chemotherapy induced reversible posterior leukoencephalopathy syndrome. Lung Cancer, 56(3), pp. 459-463.

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The reversible posterior leukoencephalopathy syndrome (RPLES) is a condition characterised by reversible neurological and radiological findings that has been associated with use of immunosuppressive, chemotherapeutic and more recently novel targeted therapies. We describe the case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy. The clinical, radiological and EEG findings during and post event are presented and are in keeping with a diagnosis of RPLES. Early recognition of this rare syndrome, supportive management and withdrawal of the offending agent appear to result in a reversal of the manifestations described. © 2007 Elsevier Ireland Ltd. All rights reserved.

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33 citations in Scopus
24 citations in Web of Science®
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ID Code: 64907
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Chemotherapy, Cisplatin, Encephalopathy, Gemcitabine, Lung malignancy, Seizures, hydralazine, labetalol, magnesium sulfate, adult, article, cancer chemotherapy, case report, clinical evaluation, electroencephalogram, epileptic state, female, human, hypertension, leukoencephalopathy, lung non small cell cancer, multiple cycle treatment, priority journal, radiological procedures, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Deoxycytidine, Diagnosis, Differential, Drug Therapy, Combination, Electroencephalography, Follow-Up Studies, Humans, Immunosuppressive Agents, Leukoencephalopathy, Progressive Multifocal, Lung Neoplasms, Magnetic Resonance Imaging, Meningeal Neoplasms, Middle Aged, Ribonucleotide Reductases, Tomography, X-Ray Computed
DOI: 10.1016/j.lungcan.2007.01.012
ISSN: 0169-5002
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Elsevier Ireland Ltd
Deposited On: 29 Nov 2013 04:57
Last Modified: 29 Nov 2013 04:59

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