Chemotherapy induced reversible posterior leukoencephalopathy syndrome
Connolly, Roisin M., Doherty, Colin P., Beddy, Peter, & O'Byrne, Kenneth J. (2007) Chemotherapy induced reversible posterior leukoencephalopathy syndrome. Lung Cancer, 56(3), pp. 459-463.
The reversible posterior leukoencephalopathy syndrome (RPLES) is a condition characterised by reversible neurological and radiological findings that has been associated with use of immunosuppressive, chemotherapeutic and more recently novel targeted therapies. We describe the case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy. The clinical, radiological and EEG findings during and post event are presented and are in keeping with a diagnosis of RPLES. Early recognition of this rare syndrome, supportive management and withdrawal of the offending agent appear to result in a reversal of the manifestations described. © 2007 Elsevier Ireland Ltd. All rights reserved.
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|Item Type:||Journal Article|
|Keywords:||Chemotherapy, Cisplatin, Encephalopathy, Gemcitabine, Lung malignancy, Seizures, hydralazine, labetalol, magnesium sulfate, adult, article, cancer chemotherapy, case report, clinical evaluation, electroencephalogram, epileptic state, female, human, hypertension, leukoencephalopathy, lung non small cell cancer, multiple cycle treatment, priority journal, radiological procedures, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Deoxycytidine, Diagnosis, Differential, Drug Therapy, Combination, Electroencephalography, Follow-Up Studies, Humans, Immunosuppressive Agents, Leukoencephalopathy, Progressive Multifocal, Lung Neoplasms, Magnetic Resonance Imaging, Meningeal Neoplasms, Middle Aged, Ribonucleotide Reductases, Tomography, X-Ray Computed|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2007 Elsevier Ireland Ltd|
|Deposited On:||29 Nov 2013 04:57|
|Last Modified:||29 Nov 2013 04:59|
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