Angiogenesis and non-small cell lung cancer

Cox, G., Jones, J. L., Walker, R. A., Steward, W. P., & O'Byrne, Kenneth J. (2000) Angiogenesis and non-small cell lung cancer. Lung Cancer, 27(2), pp. 81-100.

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Lung cancer is the commonest cause of cancer death in the western world. Recent evidence suggests that angiogenesis is related to poor prognosis in many solid tumours including non-small cell lung cancer. Angiogenesis is controlled by a complex interaction between growth and apoptotic factors, proteases and adhesion molecules. The angiogenic process may prove a target for novel therapies such as matrix metalloproteinase inhibitors, growth factor antisense RNA, growth factor receptor antagonists and naturally occurring antiangiogenic peptides. These agents may be used alone or in combination with traditional chemotherapy, radiotherapy and surgery. (C) 2000 Elsevier Science Ireland Ltd.

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65 citations in Web of Science®

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ID Code: 64912
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Angiogenesis, Apoptosis, Growth factors, Matrix metalloproteinases, Non- small cell lung cancer, angiogenesis inhibitor, angiostatin, basic fibroblast growth factor, cyclophosphamide, endostatin, fumagillol chloroacetylcarbamate, growth factor receptor antagonist, metalloproteinase inhibitor, platelet derived endothelial cell growth factor, protein bcl 2, protein p53, unclassified drug, vasculotropin receptor, article, drug mechanism, growth regulation, human, human cell, lung non small cell cancer, pathophysiology, priority journal, prognosis, Angiogenesis Inhibitors, Carcinoma, Non-Small-Cell Lung, Growth Substances, Humans, Lung Neoplasms, Neovascularization, Pathologic
DOI: 10.1016/S0169-5002(99)00096-3
ISSN: 0169-5002
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2000 Elsevier Ireland
Deposited On: 29 Nov 2013 06:52
Last Modified: 29 Nov 2013 06:53

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