The safety profile of perflutren microsphere contrast echocardiography during rest and stress imaging : results from an Australian multicentre cohort

Platts, David, Sushil, A. Luis, Roper, Damian, Burstow, Darryl, Call, Tony, Forshaw, Anthony, & Pascoe, Roess (2013) The safety profile of perflutren microsphere contrast echocardiography during rest and stress imaging : results from an Australian multicentre cohort. Heart Lung and Circulation, 22(12), pp. 996-1002.

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Contrast enhanced echocardiography (CEE) is utilised when sub-optimal image quality results in non-diagnostic echocardiograms. However, there have been numerous safety notices issued by regulatory authorities regarding rare but potentially serious adverse reactions (AR). This multi-centre, retrospective analysis was performed to assess the short-term safety of CEE in a broad range of indications.


All CEE performed over 58 months at three institutions were assessed for AR within 30 min.


A total of 5956 CEE were performed in 5576 patients. A total of 4903 were stress CEE and 1053 resting CCE.Bolus administration in 5719, infusion in 237 cases; 89.9% of CCE were outpatients. Commonest CEE indication was functional stress testing (82.3%). There were 16 AR related to CEE (0.27%). All AR were mild, transient and all patients made a full recovery. No cases of serious anaphylaxis or death within 30 min of contrast administration. Comparing those with and without an AR, there were no significant differences in age, gender, BMI, LVEF, patient location, exam type or RVSP. There was a slightly increased likelihood of an AR during infusion versus bolus dosing (p = 0.02).


CEE is a safe investigation in a broad range of indications and clinical scenarios. AR are very rare, mild and transient.

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ID Code: 64916
Item Type: Journal Article
Refereed: Yes
Keywords: Echocardiography, contrast, ultrasound, cardiac
DOI: 10.1016/j.hlc.2013.05.637
ISSN: 1443-9506
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OTHER MEDICAL AND HEALTH SCIENCES (119900) > Medical and Health Sciences not elsewhere classified (119999)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2013 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Heart Lung and Circulation. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Heart Lung and Circulation, [VOL 22, ISSUE 12, (2013)] DOI: 10.1016/j.hlc.2013.05.637
Deposited On: 17 Mar 2014 03:50
Last Modified: 02 Jan 2016 17:48

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