Prognostic significance of platelet and microvessel counts in operable non-small cell lung cancer

Cox, G., Walker, R. A., Andi, A., Steward, W. P., & O'Byrne, Kenneth J. (2000) Prognostic significance of platelet and microvessel counts in operable non-small cell lung cancer. Lung Cancer, 29(3), pp. 169-177.

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Background: Microvessel density, an indirect measure of angiogenesis, has been shown to be an independent prognostic marker in many solid tumours including non-small cell lung cancer (NSCLC). Platelets transport and release angiogenic growth factors. Platelets are increasingly likely to adhere to tumour microvessels due to raised expression of platelet-binding proteins and stasis in blood-flow. Increased vascular permeability in tumour microvessels facilitates platelet extravasation into the extracellular matrix. Adherence and extravasation both lead to platelet activation and release of growth factors capable of instigating the angiogenic process.

Methods: A total of 181 patients were identified who underwent resection of stage I-IIIa NSCLC with a post-operative survival >60 days. Patients were followed-up for a minimum of 24 months. Sections from the tumour periphery were stained for the endothelial marker CD34 (Novocastra NCL-END) using standard ABC immunohistochemistry. Chalkley counting was used to assess microvessel density.

Results: A pre-operative platelet count greater than the median and above the normal range (>400) was associated with a poor outcome (P = 0.01 and P = 0.04, respectively). Tumours with an above median and high Chalkley count (upper tertile) had a worse prognosis (P = 0.007 and P = 0.0006, respectively). There was no association between platelet count and Chalkley count.

Conclusions: Platelet and microvessel counts are both potential prognostic markers for NSCLC. The role of platelets in the angiogenic process needs to be further investigated. (C) 2000 Elsevier Science Ireland Ltd.

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51 citations in Web of Science®
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ID Code: 64960
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Angiogenesis, Non-small cell lung cancer, Platelets, angiogenic factor, binding protein, CD34 antigen, adult, aged, article, blood vessel permeability, cancer staging, cancer survival, controlled study, female, follow up, human, lung non small cell cancer, major clinical study, male, preoperative evaluation, priority journal, prognosis, thrombocyte adhesion, thrombocyte count, Carcinoma, Non-Small-Cell Lung, Immunohistochemistry, Lung Neoplasms, Middle Age, Neovascularization, Pathologic, Platelet Activation, Platelet Count, Pregnancy, Survival Analysis
DOI: 10.1016/S0169-5002(00)00124-0
ISSN: 0169-5002
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2000 Elsevier Ireland Ltd
Deposited On: 02 Dec 2013 01:57
Last Modified: 02 Dec 2013 01:57

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