EGFR expression : associations with outcome and clinicopathological variables in malignant pleural mesothelioma

Edwards, J. G., Swinson, D. E. B., Jones, J. L., Waller, D. A., & O'Byrne, Kenneth J. (2006) EGFR expression : associations with outcome and clinicopathological variables in malignant pleural mesothelioma. Lung Cancer, 54(3), pp. 399-407.

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Abstract

Malignant mesothelioma (MM) is a fatal tumour of increasing incidence which is related to asbestos exposure. This work evaluated expression in MM of Epidermal Growth Factor Receptor (EGFR) by immunohistochemistry in 168 tumour sections and its correlations with clinicopathological and biological factors. The microvessel density (MVD) was derived from CD34 immunostained sections. Hematoxylin and eosin stained sections were examined for intratumoural necrosis. COX-2 protein expression was evaluated with semi-quantitative Western blotting of homogenised tumour supernatants (n = 45). EGFR expression was correlated with survival by Kaplan-Meier and log rank analysis. Univariate and multivariate Cox proportional hazards models were used to compare the effects of EGFR with clinicopathological and biological prognostic factors and prognostic scoring systems. EGFR expression was identified in 74 cases (44%) and correlated with epithelioid cell type (p < 0.0001), good performance status (p < 0.0001), the absence of chest pain (p < 0.0001) and the presence of TN (p = 0.004), but not MVD or COX-2. EGFR expression was a good prognostic factor in univariate analysis (p = 0.01). Independent indicators of poor prognosis in multivariate analysis were non-epithelioid cell type (p = 0.0001), weight loss, performance status and WBC > 8.3 × 10 9 L -1. EGFR status was not an independent prognostic factor. EGFR expression in MM correlates with epithelioid histology and TN. EGFR may be a target for selective therapies in MM. © 2006 Elsevier Ireland Ltd. All rights reserved.

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ID Code: 65048
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Epidermal Growth Factor Receptor, Malignant mesothelioma, Prognosis, cyclooxygenase 2, eosin, hematoxylin, article, cancer diagnosis, cancer survival, controlled study, correlation analysis, epithelioid cell, female, human, immunohistochemistry, Kaplan Meier method, log rank test, major clinical study, male, multivariate analysis, pathology, performance, pleura mesothelioma, priority journal, protein expression, thorax pain, weight reduction, Humans, Membrane Proteins, Mesothelioma, Neovascularization, Pathologic, Pleural Neoplasms, Proportional Hazards Models, Receptor, Epidermal Growth Factor, Survival Analysis, Survival Rate, Tumor Markers, Biological
DOI: 10.1016/j.lungcan.2006.08.012
ISSN: 0169-5002
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Elsevier Ireland Ltd
Deposited On: 03 Dec 2013 07:04
Last Modified: 30 Jan 2014 04:04

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