Advances in the systemic therapy of malignant pleural mesothelioma

Fennell, D. A., Gaudino, G., O'Byrne, Kenneth J., Mutti, L., & van Meerbeeck, J. (2008) Advances in the systemic therapy of malignant pleural mesothelioma. Nature Clinical Practice Cardiovascular Medicine, 5(3), pp. 136-147.

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Abstract

Malignant pleural mesothelioma is an aggressive thoracic malignancy associated with exposure to asbestos, and its incidence is anticipated to increase during the first half of this century. Chemotherapy is the mainstay of treatment, yet sufficiently robust evidence to substantiate the current standard of care has emerged only in the past 5 years. This Review summarizes the evidence supporting the clinical activity of chemotherapy, discusses the use of end points for its assessment and examines the influence of clinical and biochemical prognostic factors on the natural history of malignant pleural mesothelioma. Early-phase clinical trials of second-line and novel agents are emerging from an increased understanding of mesothelioma cell biology. Coupled with high-quality translational research, such developments have real potential to improve the outlook of patients at a time of increasing incidence.

Impact and interest:

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ID Code: 65049
Item Type: Journal Article
Refereed: Yes
Keywords: Biomarkers, Chemotherapy, Mesothelioma, Novel therapy, Pleural, 3 phenylsulfamoylcinnamohydroxamic acid, 5 aza 2' deoxycytidine, alkylating agent, anthracycline, antineoplastic antimetabolite, asbestos, bevacizumab, carboplatin, cediranib, cisplatin, depsipeptide, DNA topoisomerase inhibitor, doxorubicin, flavopiridol, gemcitabine, histone deacetylase inhibitor, imatinib, mitomycin, mitoxantrone, navelbine, pemetrexed, platinum derivative, raltitrexed, sorafenib, sunitinib, taxane derivative, unindexed drug, vinblastine, Vinca alkaloid, vorinostat, anthracycline derivative, antineoplastic agent, fluorodeoxyglucose f 18, folic acid antagonist, placebo, proteome, vindesine, cancer chemotherapy, cancer incidence, cancer research, clinical trial, combination chemotherapy, disease course, drug design, drug fatality, human, malignant mesothelioma, monotherapy, patient care, pleura mesothelioma, priority journal, prognosis, review, systemic therapy, thorax cancer, biochemistry, cancer cell, cancer staging, cancer survival, computer assisted emission tomography, cytology, disease free survival, drug choice, drug efficacy, drug mechanism, drug response, drug safety, dyspnea, glioblastoma, lung surgery, multiple cycle treatment, overall survival, pain, protein targeting, survival rate, survival time, therapy delay, treatment duration, treatment planning, Antineoplastic Agents, Combined Modality Therapy, Folic Acid Antagonists, Gene Expression Profiling, Humans, Platinum Compounds, Pleural Neoplasms, Positron-Emission Tomography, Treatment Outcome, Tumor Markers, Biological
DOI: 10.1038/ncponc1039
ISSN: 1743-4297
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Nature Publishing Group
Deposited On: 03 Dec 2013 07:12
Last Modified: 11 Mar 2014 06:04

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