EUELC project : a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

Field, J.K., Liloglou, T., Niaz, A., Bryan, J., Cassidy, A., Gosney, J.R., Giles, T., Brambilla, C., Brambilla, E., Vesin, A., Timsit, J.F., Hainaut, P., Martinet, Y., Vignaud, J.M., Thunnissen, F.B., Prinsen, C., Snijders, P.J., O'Byrne, K.J., Harrison, D.J., & European Early Lung Cancer (EUELC) project (2009) EUELC project : a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration. European Respiratory Journal, 34(6), pp. 1477-1486.

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Abstract

The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular - pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARβ genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes. Copyright©ERS Journals Ltd 2009.

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ID Code: 65052
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 18 months
Additional URLs:
Keywords: Biobank, Case control, Epidemiology, European Early Lung Cancer, Genetic alterations, Nonsmall cell lung cancer, fragile histidine triad protein, telomerase reverse transcriptase, article, cancer growth, controlled study, DNA methylation, female, France, gene expression, genetic stability, genotype, Germany, human, human tissue, immunohistochemistry, Ireland, Italy, lung carcinogenesis, lung non small cell cancer, major clinical study, male, methylation, mutational analysis, Netherlands, Poland, priority journal, respiratory epithelium, Spain, United Kingdom, Aged, Carcinoma, Non-Small-Cell Lung, DNA Mutational Analysis, Epithelium, Europe, Humans, Lung Neoplasms, Middle Aged, Oligonucleotide Array Sequence Analysis, Receptors, Retinoic Acid, Telomerase
DOI: 10.1183/09031936.00077809
ISSN: 0903-1936
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 European Respiratory Society
Deposited On: 03 Dec 2013 07:37
Last Modified: 03 Feb 2015 04:37

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