Platelet-derived endothelial cell growth factor (thymidine phosphorylase) expression in lung cancer

Giatromanolaki, A., Koukourakis, M. I., Comley, M., Kaklamams, L., Turley, H., O'Byrne, Kenneth J., Harris, A. L., & Gatter, K. C. (1997) Platelet-derived endothelial cell growth factor (thymidine phosphorylase) expression in lung cancer. Journal of Pathology, 181(2), pp. 196-199.

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Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an enzyme with angiogenic and cell motility properties. Moreover, it is involved in the transformation of fluoropyrimidines into active cytotoxic metabolites, In the present study, the expression of PD-ECGF in normal lung and lung cancer was immunohistochemically evaluated using the P-GF.44C monoclonal antibody. Alveolar and tumoural macrophages mere invariably stained and mere used as an internal control for assessment of the staining. Alveolar epithelium was always negative, whilst bronchiolar epithelium showed occasional positive reactivity. Normal lung and tumour endothelium was occasionally positive, Positive staining in more than 50 per cent of cells was observed in 23/71 squamous carcinomas (32 per cent), 16/38 (42 per cent) adenocarcinomas, and 2/6 (33 per cent) adenosquamous carcinomas. Differentiated areas and areas of squamous metaplasia mere more strongly positive than other tumour areas. All 22 small cell carcinomas and one carcinoid tumour were negative. The present study provides a baseline for future studies in non-small cell lung cancer to correlate PD-ECGF expression with tumour vascularization, prognosis, and response to chemotherapy.

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ID Code: 65074
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Lung cancer, Platelet-derived endothelial cell growth factor, Thymidine phosphorylase, platelet derived endothelial cell growth factor, adenocarcinoma, angiogenesis, article, carcinosarcoma, controlled study, human, human tissue, immunohistochemistry, lung carcinoma, lung small cell cancer, major clinical study, priority journal, squamous cell carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Endothelial Growth Factors, Humans, Immunoenzyme Techniques, Lung, Lung Neoplasms, Neoplasm Proteins
DOI: 10.1002/(SICI)1096-9896(199702)181:2<196::AID-PATH763>3.0.CO;2-U
ISSN: 0022-3417
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1997 John Wiley & Sons Ltd.
Deposited On: 04 Dec 2013 02:05
Last Modified: 04 Dec 2013 02:05

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