Invading edge vs. inner (edvin) patterns of vascularization : an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer

Giatromanolaki, A., Koukourakis, M. I., Sivridis, E., O'Byrne, Kenneth J., Gatter, K. C., & Harris, A. L. (2000) Invading edge vs. inner (edvin) patterns of vascularization : an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer. Journal of Pathology, 192(2), pp. 140-149.

View at publisher

Abstract

Neo-angiogenesis during neoplastic growth involves endothelial mitogenic and migration stimuli produced by cancer or tumour stromal cells. Although this active angiogenesis takes place in the tumour periphery, the process of vessel growth and survival in inner areas and its clinical role remain largely unexplored. The present study compared the microvessel score (MS) as well as the single endothelial cell score (ECS) in the invading edge and in inner areas of non-small cell lung carcinomas (NSCLCs). Three different patterns of vascular growth were distinguished: the edvin (edge vs. inner) type 1, where a low MS was observed in both peripheral and inner tumour areas; the edvin type 2, where a high MS was noted in the invading front but a low MS in inner areas; and the edvin type 3, where both peripheral and inner tumour areas had a high MS. The ECS was high in the invading edge in edvin type 2 and 3 cases and was sharply decreased in both types in inner areas, suggesting that endothelial cell migration is unlikely to contribute to the angiogenic process in areas away from the tumour front. Expression of the vascular endothelial growth factor (VEGF) and of thymidine phosphorylase (TP) was associated with a high MS in the invading edge. VEGF was associated with a high MS in inner areas (edvin 3), while TP expression was associated with edvin type 2, showing that VEGF (and not TP) contributes to the preservation of the inner vasculature. Both edvin type 2 and 3 cases showed an increased incidence of node metastasis, but edvin type 3 cases had a poorer prognosis, even in the N1-stage group. The present study suggests that tumour factors regulating angiogenesis and vascular survival are not identical. A possible method is reported to quantify these two parameters by comparing the MS in the invading edge and inner areas (edvin types). This observation may contribute to the evaluation of the effectiveness of different therapeutic approaches, namely vascular targeting vs. anti-angiogenesis. Copyright (C) 2000 John Wiley and Sons, Ltd.

Impact and interest:

48 citations in Scopus
Search Google Scholar™
44 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 65075
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Angiogenesis patterns, Non-small cell lung cancer, Thymidine phosphorylase, Vascular survival, VEGF, angiogenesis inhibitor, vasculotropin, angiogenesis, article, cancer chemotherapy, cancer growth, cancer staging, cell migration, endothelium cell, human, human tissue, lung non small cell cancer, lymph node metastasis, microvasculature, mitogenesis, priority journal, prognosis, protein expression, scoring system, survival, tumor vascularization, Carcinoma, Non-Small-Cell Lung, Cell Count, Cell Movement, Cell Survival, Comparative Study, Endothelial Growth Factors, Endothelium, Vascular, Lung Neoplasms, Lymphatic Metastasis, Neoplasm Invasiveness, Neovascularization, Pathologic
DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH693>3.0.CO;2-R
ISSN: 0022-3417
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2000 John Wiley & Sons Ltd.
Deposited On: 04 Dec 2013 02:09
Last Modified: 04 Dec 2013 02:09

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page