Quality of life and survival in patients treated with radical chemoradiation alone for oesophageal cancer

Gillham, C. M., Aherne, N., Rowley, S., Moore, J., Hollywood, D., O'Byrne, Kenneth J., & Reynolds, J. V. (2008) Quality of life and survival in patients treated with radical chemoradiation alone for oesophageal cancer. Clinical Oncology, 20(3), pp. 227-233.

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Aims: To report cancer-specific and health-related quality-of-life outcomes in patients undergoing radical chemoradiation (CRT) alone for oesophageal cancer.

Materials and methods: Between 1998 and 2005, 56 patients with oesophageal cancer received definitive radical CRT, due to local disease extent, poor general health, or patient choice. Data from European Organization for Research and Treatment of Cancer quality-of-life questionnaires QLQ-30 and QLQ-OES24 were collected prospectively. Questionnaires were completed at diagnosis, and at 3, 6 and 12 months after CRT where applicable.

Results: The median follow-up was 18 months. The median overall survival was 14 months, with a 51, 26 and 13% 1-, 3- and 5-year survival, respectively. At 12 months after treatment there was a significant improvement compared with before treatment with respect to dysphagia and pain. Global health scores were not significantly affected.

Conclusions: Considering the relatively short long-term survival for this cohort of patients, maximising the quality of those final months should be very carefully borne in mind from the outset. The health-related quality-of-life data reported herein helps to establish benchmarks for larger evaluation within randomised clinical trials. © 2007 The Royal College of Radiologists.

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ID Code: 65077
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Chemoradiation, oesophageal cancer, quality of life, antineoplastic agent, carboplatin, cisplatin, fluorouracil, infusion fluid, adult, aged, article, cancer chemotherapy, cancer pain, cancer patient, cancer radiotherapy, cancer survival, cohort analysis, continuous infusion, controlled study, data analysis, drug substitution, drug withdrawal, dysphagia, esophagus cancer, European Organization for Research and Treatment of Cancer quality of life questionnaire, female, follow up, gastrointestinal toxicity, health status, hearing impairment, histopathology, human, human tissue, infection, major clinical study, male, multiple cycle treatment, nephrotoxicity, outcome assessment, overall survival, patient decision making, priority journal, prospective study, questionnaire, scoring system, survival rate, survival time, Chemotherapy, Adjuvant, Esophageal Neoplasms, Health Status Indicators, Humans, Middle Aged, Prospective Studies, Psychological Tests, Psychometrics, Questionnaires, Radiotherapy, Adjuvant, Treatment Outcome
DOI: 10.1016/j.clon.2007.12.002
ISSN: 0936-6555
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 W.B. Saunders Co. Ltd.
Deposited On: 04 Dec 2013 02:17
Last Modified: 11 Mar 2014 06:38

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