18FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response

Gillham, C. M., Lucey, J. A., Keogan, M., Duffy, G. J., Malik, V., Raouf, A. A., O'Byrne, Kenneth J., Hollywood, D., Muldoon, C., & Reynolds, J. V. (2006) 18FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response. British Journal of Cancer :BJC, 95(9), pp. 1174-1179.

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To determine whether [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) could predict the pathological response in oesophageal cancer after only the first week of neoadjuvant chemoradiation. Thirty-two patients with localised oesophageal cancer had a pretreatment PET scan and a repeat after the first week of chemoradiation. The change in mean maximum standardised uptake value (SUV) and volume of metabolically active tissue (MTV) was compared with the tumour regression grade (TRG) in the final histology. Those who achieved a TRG of 1 and 2 were deemed responders and 3-5 nonresponders. In the responders (28%), the SUV fell from 12.6 (±6.3) to 8.1 (±2.9) after 1 week of chemoradiation (P = 0.070). In nonresponders (72%), the results were 9.7 (±5.4) and 7.1 (±3.8), respectively (P = 0.003). The MTV in responders fell from 36.6 (±22.7) to 22.3 (±10.4) cm3 (P = 0.180), while in nonresponders, this fell from 35.9 (±36.7) to 31.9 (±52.7) cm3 (P = 0.405). There were no significant differences between responders and nonresponders. The hypothesis that early repeat FDG-PET scanning may predict histomorphologic response was not proven. This may reflect an inflammatory effect of radiation that obscures tumour-specific metabolic changes at this time. This assessment may have limited application in predicting response to multimodal regimens for oesophageal cancer. © 2006 Cancer Research UK.

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ID Code: 65078
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Neoadjuvant chemoradiation, Oesophageal cancer, Positron emission tomography, Response, antineoplastic agent, cisplatin, fluorodeoxyglucose f 18, adult, aged, article, chemotherapy, clinical article, controlled study, drug uptake, esophagus cancer, female, histology, human, human tissue, male, priority journal, radiation dose, tumor regression, Esophageal Neoplasms, Esophagus, Fluorodeoxyglucose F18, Humans, Middle Aged, Prognosis, Reproducibility of Results, Sensitivity and Specificity, Tomography, Emission-Computed
DOI: 10.1038/sj.bjc.6603412
ISSN: 0007-0920
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Nature Publishing Group
Deposited On: 04 Dec 2013 02:27
Last Modified: 30 Jan 2014 04:42

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