A computer image analysis system for microvessel density measurement in solid tumours

Goddard, J. C., Sutton, C. D., Furness, P. N., Kockelbergh, R. C., & O'Byrne, Kenneth J. (2002) A computer image analysis system for microvessel density measurement in solid tumours. Angiogenesis, 5(1-2), pp. 15-20.

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Microvessel density (MVD) is a widely used surrogate measure of angiogenesis in pathological specimens and tumour models. Measurement of MVD can be achieved by several methods. Automation of counting methods aims to increase the speed, reliability and reproducibility of these techniques. The image analysis system described here enables MVD measurement to be carried out with minimal expense in any reasonably equipped pathology department or laboratory. It is demonstrated that the system translates easily between tumour types which are suitably stained with minimal calibration. The aim of this paper is to offer this technique to a wider field of researchers in angiogenesis.

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21 citations in Scopus
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ID Code: 65118
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Angiogenesis, Image analysis, Microvessel density, CD34 antigen, diaminobenzidine, article, automation, calibration, computer analysis, histopathology, human, human cell, human tissue, measurement, medical research, microvasculature, pathological anatomy, priority journal, solid tumor, tumor classification, tumor model, Blood Vessels, Humans, Image Processing, Computer-Assisted, Neoplasms, Urinary Bladder Neoplasms
DOI: 10.1023/A:1021518315757
ISSN: 0969-6970
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 Springer Netherlands
Deposited On: 05 Dec 2013 00:32
Last Modified: 05 Dec 2013 00:32

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