Reduced Thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer

Goddard, J. C., Sutton, C. D., Jones, J. L., O'Byrne, Kenneth J., & Kockelbergh, R. C. (2002) Reduced Thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer. European Urology, 42(5), pp. 464-468.

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Abstract

Objectives: Superficial bladder cancer (SBC) presents a difficult clinical dilemma at diagnosis as only a small subgroup of patients will subsequently develop invasive disease. Study of cancer biology has found that angiogenesis is central to growth and spread. This study examines the relationship between the angiogenic inhibitory factor Thrombospondin-1 (TSP-1) at initial presentation and subsequent progression of SBC. Methods: Using immunohistochemistry, 220 cases of SBC were examined for pattern and extent of expression of TSP-1 at initial presentation. Results: TSP-1 was detected in perivascular tissue, at the epithelial-stromal junction, in the stroma and in tumour cells and reduced perivascular TSP-1 staining at presentation was an independent predictive factor for the subsequent development of muscle invasive or metastatic disease. Conclusion: This adds further weight to the theory that TSP-1 plays a major part in the biology of bladder cancer possibly through the control of angiogenesis. © 2002 Elsevier Science B.V. All rights reserved.

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17 citations in Scopus
17 citations in Web of Science®
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ID Code: 65120
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Angiogenesis, Bladder cancer, Image analysis, Immunohistochemistry, Thrombospondin, thrombospondin 1, tumor marker, adult, aged, article, bladder tumor, cancer invasion, disease course, female, human, male, metabolism, middle aged, multivariate analysis, pathology, cancer growth, human tissue, metastasis, priority journal, protein expression, tumor cell, Aged, 80 and over, Disease Progression, Humans, Neoplasm Invasiveness, Tumor Markers, Biological, Urinary Bladder Neoplasms
DOI: 10.1016/S0302-2838(02)00372-X
ISSN: 0302-2838
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 Elsevier BV
Deposited On: 05 Dec 2013 00:40
Last Modified: 20 Jul 2017 02:01

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