F-actin crosslinker : a key player for the mechanical stability of filopodial protrusion

Li, Tong, Oloyede, Adekunle, & Gu, YuanTong (2013) F-actin crosslinker : a key player for the mechanical stability of filopodial protrusion. Journal of Applied Physics, 114(21).

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Filopodial protrusion initiates cell migration, which decides the fate of cells in biological environments. In order to understand the structural stability of ultra-slender filopodial protrusion, we have developed an explicit modeling strategy that can study both static and dynamic characteristics of microfilament bundles. Our study reveals that the stability of filopodial protrusions is dependent on the density of F-actin crosslinkers. This cross-linkage strategy is a requirement for the optimization of cell structures, resulting in the provision and maintenance of adequate bending stiffness and buckling resistance while mediating the vibration. This cross-linkage strategy explains the mechanical stability of filopodial protrusion and helps understand the mechanisms of mechanically induced cellular activities.

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2 citations in Scopus
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1 citations in Web of Science®

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51 since deposited on 08 Dec 2013
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ID Code: 65170
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: F-actin crosslinker, Filopodial protrusion, Biomechanics, Mechanical stability
DOI: 10.1063/1.4839715
ISSN: 0021-8979
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 AIP Publishing LLC
Deposited On: 08 Dec 2013 23:17
Last Modified: 15 Apr 2014 13:02

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