Potential role of bcl-2 as a suppressor of tumour angiogenesis in non- small-cell lung cancer

Koukourakis, M. I., Giatromanolaki, A., O'Byrne, Kenneth J., Whitehouse, R. M., Talbot, D. C., Gatter, K. C., & Harris, A. L. (1997) Potential role of bcl-2 as a suppressor of tumour angiogenesis in non- small-cell lung cancer. International Journal of Cancer, 74(6), pp. 565-570.

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Abstract

It has been reported that genes regulating apoptosis may play a role in tumoral angiogenesis. This study examined the relationship between tumour vascularization, a measure of tumour angiogenesis, and bcl-2 and p53 expression in operable non-small-cell lung cancer (NSCLC). The relationship between bcl-2, p53 and tumour vascularization and epidermal-growth-factor- receptor(EGFR) and c-erbB-2 expression was also studied. Tissue sections from resected tumour specimens of 107 NSCLC patients were evaluated immunohistochemically for vascular grade and bcl-2, p53, EGFR and c-erbB-2 expression. bcl-2 expression was found in 20/107 (19%) cases and was associated with squamous-cell histology (p = 0.03). A strong inverse relationship was found between bcl-2 expression and vascular grade (p = 0.005). All c-erbB-2-positive cases were negative for bcl-2 expression (p = 0.01). Overall no association was found between c-erbB-2 expression and vascular grade. However, in bcl-2-negative cases positive c-erbB-2 expression correlated with low angiogenesis (p = 0.05). No relationship was found between p53 and EGFR expression and bcl-2, c-erbB-2 or vascular grade. The improved prognosis reported in bcl-2-positive NSCLC may be related to low tumour vascularization. The results suggest that the anti-apoptotic gene bcl- 2 plays a role in regulating tumour angiogenesis. Since normal lung epithelium expresses bcl-2, a sequence of tumour progression involving loss of bcl-2, then activation of c-erbB-2 or increase in tumour vascularization is proposed.

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ID Code: 65176
Item Type: Journal Article
Refereed: Yes
Additional Information:
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Keywords: epidermal growth factor receptor, protein bcl 2, protein p53, tyrosine kinase receptor, adult, aged, angiogenesis, apoptosis, article, cancer grading, cancer growth, female, gene expression, human, immunohistochemistry, lung cancer, lung non small cell cancer, major clinical study, male, priority journal, Analysis of Variance, Carcinoma, Non-Small-Cell Lung, Genes, bcl-2, Genes, p53, Genes, Tumor Suppressor, Humans, Lung Neoplasms, Middle Aged, Neovascularization, Pathologic, Proto-Oncogene Proteins c-bcl-2, Receptor Protein-Tyrosine Kinases, Receptor, Epidermal Growth Factor, Retrospective Studies, Survival Analysis, Tumor Suppressor Protein p53
DOI: 10.1002/(SICI)1097-0215(19971219)74:6<565::AID-IJC1>3.0.CO;2-S
ISSN: 0020-7136
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1997 John Wiley & Sons, Inc.
Deposited On: 06 Dec 2013 02:13
Last Modified: 06 Dec 2013 02:13

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