A single institution experience of streptozocin/fluorouracil combination chemotherapy : a case series

Naidoo, J., O'Toole, D., Kennedy, M. J., Reynolds, J. V., O'Connor, M., & O'Byrne, Kenneth J. (2012) A single institution experience of streptozocin/fluorouracil combination chemotherapy : a case series. Irish Journal of Medical Science, 181(2), pp. 211-214.

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Background The combination chemotherapy regimen of streptozocin and 5-fluorouracil (FU/STZ) has been used for the treatment of metastatic neuroendocrine tumours.

Aim The aim of this study was to analyse the use of this regimen in a tertiary oncology referral centre over a 10-year period.

Method We retrospectively analysed nine cases from February 2000 to May 2010. Patient demographics, chemotherapy schedule, toxicities, progression-free and overall survival were tabulated for each patient.

Result The median progression-free survival was 17 months (range 3-48+ months), and overall survival 31 months (range 12-53+ months) with no toxicity related deaths.

Conclusion FU/STZ was a well-tolerated regimen that produced significant benefit in the setting of metastatic and progressive disease. Our case series demonstrated comparable progression-free survival and overall survival in relation to randomized controlled studies and previous case series. © Royal Academy of Medicine in Ireland 2011.

Impact and interest:

3 citations in Scopus
3 citations in Web of Science®
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ID Code: 65229
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Fluorouracil, Metastatic, Neuroendocrine, Streptozocin, Tumour, dacarbazine, doxorubicin, adult, aged, alopecia, anemia, article, clinical article, combination chemotherapy, demography, diarrhea, drug tolerability, endocrine disease, fatigue, female, human, intestine obstruction, kidney disease, leukopenia, male, metastasis, mucosa inflammation, multiple cycle treatment, nausea, neuroendocrine tumor, neutropenia, overall survival, progression free survival, retrospective study, sepsis, skin disease, thrombocytopenia, treatment outcome, vomiting, Antibiotics, Antineoplastic, Antimetabolites, Antineoplastic, Carcinoid Tumor, Disease-Free Survival, Drug Therapy, Combination, Humans, Middle Aged, Neuroendocrine Tumors
DOI: 10.1007/s11845-011-0780-7
ISSN: 0021-1265
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Springer U K
Deposited On: 09 Dec 2013 06:18
Last Modified: 20 Jul 2017 03:01

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