Radiolabelled somatostatin analogue scintigraphy in oncology

O'Byrne, Kenneth J. & Carney, Desmond N. (1996) Radiolabelled somatostatin analogue scintigraphy in oncology. Anti-Cancer Drugs, 7(SUP1), pp. 33-44.

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Abstract

Somatostatin analogue scintigraphy represents a new technique employing radiolabelled peptides to detect specific receptor-bearing lesions. 111Indium diethylenetriaminopentaacetic acid-linked octreotide (111In-DTPA-D-Phe1 octreotide), also known as [111In]pentetreotide or OctreoScan, is now established in the management of patients with neuroendocrine gastrointestinal tract and pancreatic tumours, and has proved effective in localizing disease sites in lung, breast and medullary thyroid carcinomas, lymphomas, meningiomas and others. In these conditions (a) the imaging of all disease sites at a single sitting (in a proportion of patients) thereby making further investigations unnecessary, (b) the localization of otherwise unexpected metastatic deposits and (c) the detection of residual disease not found by other means suggest that [111In]pentetreotide may be a useful adjunct in the diagnostic evaluation of patients with somatostatin receptor-bearing tumours.

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20 citations in Web of Science®

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ID Code: 65253
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Diagnosis, Scintigraphy, Somatostatin analogue, Somatostatin receptor, angiopeptin, iodine 123, octreotide, pentetreotide, pentetreotide in 111, radioisotope, somatostatin derivative, vapreotide, animal model, breast cancer, cancer scintiscanning, clinical trial, drug penetration, gastrointestinal tumor, human, lung non small cell cancer, lung small cell cancer, lymphoma, meningioma, neuroendocrine system, nonhuman, pancreas tumor, priority journal, review, technique, thyroid medullary carcinoma, tumor localization, Breast Neoplasms, Carcinoma, Small Cell, Hormone Antagonists, Humans, Indium Radioisotopes, Lung Neoplasms, Neoplasms, Receptors, Somatostatin, Somatostatin
DOI: 10.1097/00001813-199601001-00006
ISSN: 0959-4973
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1996 Lippincott Williams & Wilkins
Deposited On: 10 Dec 2013 02:32
Last Modified: 10 Dec 2013 02:33

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