Chronic immune activation and inflammation as the cause of malignancy

O'Byrne, Kenneth J. & Dalgleish, A. G. (2001) Chronic immune activation and inflammation as the cause of malignancy. British Journal of Cancer, 85(4), pp. 473-483.

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Several chronic infections known to be associated with malignancy have established oncogenic properties. However the existence of chronic inflammatory conditions that do not have an established infective cause and are associated with the development of tumours strongly suggests that the inflammatory process itself provides the prerequisite environment for the development of malignancy. This environment includes upregulation of mediators of the inflammatory response such as cyclo-oxygenase (COX)-2 leading to the production of inflammatory cytokines and prostaglandins which themselves may suppress cell mediated immune responses and promote angiogenesis. These factors may also impact on cell growth and survival signalling pathways resulting in induction of cell proliferation and inhibition of apoptosis. Furthermore, chronic inflammation may lead to the production of reactive oxygen species and metabolites such as malondialdehyde within the affected cells that may in turn induce DNA damage and mutations and, as a result, be carcinogenic. Here it is proposed that the conditions provided by a chronic inflammatory environment are so essential for the progression of the neoplastic process that therapeutic intervention aimed at inhibiting inflammation, reducing angiogenesis and stimulating cell mediated immune responses may have a major role in reducing the incidence of common cancers. © 2001 Cancer Research Campaign

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ID Code: 65255
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Angiogenesis, Cancer, Cell mediated immunity, Humoral immunity, carcinogen, cyclooxygenase 2, cytokine, DNA, malonaldehyde, prostaglandin, reactive oxygen metabolite, apoptosis, cancer incidence, cancer susceptibility, carcinogenesis, carcinogenicity, cell growth, cell proliferation, cell survival, cellular immunity, chronic inflammation, cytokine production, DNA damage, gene mutation, human, immunoreactivity, priority journal, prostaglandin synthesis, protein expression, review, signal transduction, virus cell interaction, virus infection, Wart virus, Cell Transformation, Neoplastic, Chronic Disease, Cytokines, Humans, Inflammation, Isoenzymes, Malondialdehyde, Membrane Proteins, Neoplasms, Neovascularization, Pathologic, Prostaglandin-Endoperoxide Synthases, Prostaglandins
DOI: 10.1054/bjoc.2001.1943
ISSN: 0007-0920
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: © 2001 Cancer Research Campaign
Deposited On: 10 Dec 2013 02:41
Last Modified: 23 Mar 2015 00:39

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