The role of inflammation in the pathogenesis of non-small cell lung cancer

O'Callaghan, D. S., O'Donnell, D., O'Connell, F., & O'Byrne, Kenneth J. (2010) The role of inflammation in the pathogenesis of non-small cell lung cancer. Journal of Thoracic Oncology, 5(12), pp. 2024-2036.

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The link between chronic immune activation and tumorigenesis is well established. Compelling evidence has accumulated that histologic assessment of infiltration patterns of different host immune response components in non-small cell lung cancer specimens helps identify different prognostic patient subgroups. This review provides an overview of recent insights gained in the understanding of the role played by chronic inflammation in lung carcinogenesis. The usefulness of quantification of different populations of lymphocytes, natural killer cells, macrophages, and mast cells within the tumor microenvironment in non-small cell lung cancer is also discussed. In particular, the importance of assessment of inflammatory cell microlocalization within both the tumor islet and surrounding stromal components is emphasized. Copyright © 2010 by the International Association for the Study of Lung Cancer.

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ID Code: 65292
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Immunohistochemistry, Inflammation, Lymphocyte, Macrophage, Non-small cell lung cancer, cyclooxygenase 1, cyclooxygenase 2, epidermal growth factor receptor, gamma interferon, gemcitabine, interleukin 10, interleukin 12, interleukin 13, interleukin 2, interleukin 4, interleukin 5, interleukin 6, T lymphocyte receptor, tobacco smoke, tumor necrosis factor alpha, article, bone marrow cell, CD4+ T lymphocyte, cell infiltration, cell population, cell proliferation, cellular distribution, cellular immunity, chlamydial pneumonia, chronic inflammation, chronic obstructive lung disease, cigarette smoking, cytokine production, cytokine release, dendritic cell, dust, fibrosing alveolitis, forced expiratory volume, gene mutation, histopathology, human, humoral immunity, immune response, immunopathogenesis, inflammatory cell, lung carcinogenesis, lung infection, lung non small cell cancer, major histocompatibility complex, mast cell, Mycobacterium tuberculosis, natural killer cell, nonhuman, occupational exposure, pathogenesis, priority journal, prognosis, signal transduction, T lymphocyte, tumor microenvironment, Adaptive Immunity, Animals, Carcinoma, Non-Small-Cell Lung, CD4-Positive T-Lymphocytes, Chronic Disease, Humans, Immunity, Cellular, Lung Neoplasms, Pulmonary Disease, Chronic Obstructive, Tobacco Smoke Pollution
DOI: 10.1097/JTO.0b013e3181f387e4
ISSN: 1556-0864
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Lippincott Williams & Wilkins
Deposited On: 11 Dec 2013 02:36
Last Modified: 17 Mar 2014 02:55

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