Cisplatin and gemcitabine in the management of metastatic penile cancer

Power, Derek G., Galvin, David J., Cuffe, Sinead, McVey, Gerald P., Mulholland, Paul J., Farrelly, Cormac, Delaney, David W., & O'Byrne, Kenneth J. (2009) Cisplatin and gemcitabine in the management of metastatic penile cancer. Urologic Oncology : Seminars and Original Investigations, 27(2), pp. 187-190.

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Abstract

Penile cancer is rare and receives little public attention. There are few treatment options for advanced disease. The most active regimen to date is a combination of bleomycin, methotrexate, and cisplatin. However the treatment-related mortality is 11% and hence this combination has not been adapted as a standard of care. We report two cases of advanced penile cancer where a sustained palliative response was observed with combination chemotherapy using cisplatin and gemcitabine. Our experience demonstrates that this is a well tolerated regimen active in this setting. © 2009 Elsevier Inc. All rights reserved.

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ID Code: 65373
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Cancer, Chemotherapy, Metastatic, Penile, Radiotherapy, carboplatin, cisplatin, gemcitabine, adult, anamnesis, article, cancer chemotherapy, cancer staging, case report, computer assisted tomography, drug substitution, drug tolerability, drug withdrawal, human, human tissue, inguinal lymph node, lymphadenectomy, lymphadenopathy, male, metastasis, multiple cycle treatment, palliative therapy, penile biopsy, penis amputation, penis cancer, priority journal, squamous cell carcinoma, tinnitus, treatment response, Aged, Antineoplastic Combined Chemotherapy Protocols, Biopsy, Bleomycin, Carcinoma, Squamous Cell, Deoxycytidine, Humans, Methotrexate, Middle Aged, Penile Neoplasms, Tomography, X-Ray Computed, Treatment Outcome
DOI: 10.1016/j.urolonc.2007.10.015
ISSN: 1078-1439
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 Elsevier Inc.
Deposited On: 12 Dec 2013 23:35
Last Modified: 12 Mar 2014 06:55

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