Multiscale investigation of microfilament networks disruption in living cells

Li, Tong, Gu, YuanTong, Yarlagadda, Prasad K.D.V., & Oloyede, Adekunle (2013) Multiscale investigation of microfilament networks disruption in living cells. In Yu, Shouwen (Ed.) 13th International Conference on Fracture, 16-21 June 2013, Beijing, China.


Actin is the most abundantly distributed protein in living cells which plays critical roles in the cell interior force generation and transmission. The fracture mechanism of microfilament networks, whose principle component is actin, would provide insights which can contribute to the understandings of self-protective characters of cytoskeleton. In this study, molecular simulations are conducted to investigate the molecular mechanisms of disruption of microfilament networks from the viewpoint of biophysics. By employing a coarse-grained (CG) model of actin filament networks, we focused on the ultimate strength and crack growth mode of microfilament networks that have dependency on the crack length. It can be found that, the fracture mechanism of microfilament network has dependency on the structural properties of microfilament networks. The structure flaws marginally change the strength of microfilament networks which would explain the self-protective characters of cytoskeleton.

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ID Code: 65453
Item Type: Conference Paper
Refereed: Yes
Additional URLs:
Keywords: Actin, Fracture, Microfilament networks, Multiscale
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 please consult the authors
Deposited On: 18 Dec 2013 05:22
Last Modified: 15 May 2014 00:46

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