Characteristics of nontuberculous mycobacteria from a municipal water distribution system and their relevance to human infections
Thomson, Rachel M (2013) Characteristics of nontuberculous mycobacteria from a municipal water distribution system and their relevance to human infections. PhD by Publication, Queensland University of Technology.
This thesis documented pathogenic species of nontuberculous mycobacteria in the Brisbane water distribution system. When water and shower aerosol strains were compared with human strains of mycobacteria, the study found that the likelihood of acquiring infection from municipal water was specific for four main species. The method for isolation of mycobacteria from water was refined, followed by sampling from 220 sites across Brisbane. A variety of species (incl 15 pathogens) were identified and genotypically compared to human strains. For M. abscessus and M. lentiflavum, water strains clustered with human strains. Pathogenic strains of M. kansasii were found, though non-pathogenic strains dominated. Waterborne strains of M. fortuitum differed to human strains. Extensive home sampling of 20 patients with NTM disease, supported the theory that the risk of acquiring NTM from water or shower aerosols appears species specific for M. avium, M. kansasii, M. lentiflavum and M. abscessus.
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|Item Type:||QUT Thesis (PhD by Publication)|
|Supervisor:||Hargreaves, Megan & Huygens, Flavia|
|Additional Information:||Recipient of 2013 Outstanding Doctoral Thesis Award.|
|Keywords:||nontuberculous mycobacteria, water, distribution systems, biofilm, aerosols, genotyping, environmental organisms, rep-PCR, ODTA|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||07 Jan 2014 23:40|
|Last Modified:||07 Sep 2015 21:43|
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