The role of Y-box binding protein 1 in prostate cancer

Pokorny, Morgan R. (2013) The role of Y-box binding protein 1 in prostate cancer. PhD thesis, Queensland University of Technology.

Abstract

This thesis examined the possible role of Y-box binding protein 1 (YBX1) in prostate cancer aggression and spread. Novel roles were uncovered for YBX1 in the regulation of several genes previously implicated in prostate cancer, as well as showing an effect for YBX1 in increasing tumour cell invasion and movement and reciprocal regulation of androgen-regulated gene networks. In addition, it was found that Y-box 1 regulated several other well-known cancer genes implicated in breast and other cancers. The work performed in this thesis has strengthened the foundations for pursuing YBX1 as a possible central target molecule in prostate cancer therapeutics.

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ID Code: 65556
Item Type: QUT Thesis (PhD)
Supervisor: Nelson, Colleen & Clements, Judith
Keywords: Y box binding protein 1, YBX1, prostate cancer, androgen receptor, pseudogenes, EMT, microarray, CD82, CHEK2, RAC1
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 08 Jan 2014 01:01
Last Modified: 07 Sep 2015 01:07

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