Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapy
Sharma, Ricky A., Decatris, Marios P., Santhanam, Sundar, Roy, Rajarshi, Osman, Ahmed E., Clarke, Christine B., Khanna, Subhash, & O'Byrne, Kenneth J. (2003) Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapy. Cancer Chemotherapy and Pharmacology, 52(5), pp. 367-370.
Purpose: The development of liver metastases from breast cancer is associated with a very poor prognosis, estimated at 4 months median survival. Since treatment with many chemotherapeutic agents is relatively contraindicated, we assessed the safety, tolerability and potential efficacy of combination chemotherapy with vinorelbine and cisplatin (ViP).
Method: Pilot study in 11 patients with histologically confirmed breast carcinoma, radiological evidence of liver metastases and serum bilirubin greater than 1.5 times the upper limit of normal. Patients received up to six cycles of cisplatin (75 mg/m 2) every 21 days and vinorelbine (20 mg/m 2) on days 1 and 8 of every 21-day cycle. Measurement of liver lesions was performed on CT scan every 8 weeks into treatment.
Results: The most frequently reported adverse event was myelosuppression. Other adverse effects included nausea, vomiting and mild neurotoxicity. Two patients died after one treatment with ViP, one of whom suffered an intracerebral haemorrhage that was possibly treatment-related. Improvement in liver function tests was observed in 10 patients, and mean time to normalization of bilirubin levels was 36 days. Partial responses were documented radiologically in 7 out of 11 patients treated. Median overall survival from trial entry was 6.5 months (range 11-364 days), with one patient alive 13 months from trial entry.
Conclusion: Normalization of liver function is possible with ViP treatment of metastatic breast cancer, offering the potential to prolong survival. Phase II clinical trials of this regimen in this patient group should include measurement of quality of life in order to assess risk versus benefit.
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|Item Type:||Journal Article|
|Keywords:||Jaundice, Palliation, Platinum, Vinca, bilirubin, cisplatin, navelbine, platinum derivative, Vinca alkaloid, adult, aged, anemia, article, bilirubin blood level, bone marrow suppression, brain hemorrhage, breast cancer, cancer combination chemotherapy, cancer palliative therapy, cardiotoxicity, clinical article, computer assisted tomography, drug efficacy, drug safety, drug tolerability, female, human, liver failure, liver function, liver metastasis, nausea, nephrotoxicity, neurotoxicity, neutropenia, pilot study, priority journal, prognosis, survival rate, thrombocytopenia, vomiting, Aged, 80 and over, Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Diseases, Breast Neoplasms, Humans, Liver Function Tests, Liver Neoplasms, Middle Aged, Pilot Projects, Survival Analysis, Tomography, X-Ray Computed, Vinblastine|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2003 Springer|
|Deposited On:||06 Jan 2014 04:27|
|Last Modified:||06 Jan 2014 04:31|
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