Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapy

Sharma, Ricky A., Decatris, Marios P., Santhanam, Sundar, Roy, Rajarshi, Osman, Ahmed E., Clarke, Christine B., Khanna, Subhash, & O'Byrne, Kenneth J. (2003) Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapy. Cancer Chemotherapy and Pharmacology, 52(5), pp. 367-370.

View at publisher


Purpose: The development of liver metastases from breast cancer is associated with a very poor prognosis, estimated at 4 months median survival. Since treatment with many chemotherapeutic agents is relatively contraindicated, we assessed the safety, tolerability and potential efficacy of combination chemotherapy with vinorelbine and cisplatin (ViP).

Method: Pilot study in 11 patients with histologically confirmed breast carcinoma, radiological evidence of liver metastases and serum bilirubin greater than 1.5 times the upper limit of normal. Patients received up to six cycles of cisplatin (75 mg/m 2) every 21 days and vinorelbine (20 mg/m 2) on days 1 and 8 of every 21-day cycle. Measurement of liver lesions was performed on CT scan every 8 weeks into treatment.

Results: The most frequently reported adverse event was myelosuppression. Other adverse effects included nausea, vomiting and mild neurotoxicity. Two patients died after one treatment with ViP, one of whom suffered an intracerebral haemorrhage that was possibly treatment-related. Improvement in liver function tests was observed in 10 patients, and mean time to normalization of bilirubin levels was 36 days. Partial responses were documented radiologically in 7 out of 11 patients treated. Median overall survival from trial entry was 6.5 months (range 11-364 days), with one patient alive 13 months from trial entry.

Conclusion: Normalization of liver function is possible with ViP treatment of metastatic breast cancer, offering the potential to prolong survival. Phase II clinical trials of this regimen in this patient group should include measurement of quality of life in order to assess risk versus benefit.

Impact and interest:

10 citations in Scopus
Search Google Scholar™
10 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 65680
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Jaundice, Palliation, Platinum, Vinca, bilirubin, cisplatin, navelbine, platinum derivative, Vinca alkaloid, adult, aged, anemia, article, bilirubin blood level, bone marrow suppression, brain hemorrhage, breast cancer, cancer combination chemotherapy, cancer palliative therapy, cardiotoxicity, clinical article, computer assisted tomography, drug efficacy, drug safety, drug tolerability, female, human, liver failure, liver function, liver metastasis, nausea, nephrotoxicity, neurotoxicity, neutropenia, pilot study, priority journal, prognosis, survival rate, thrombocytopenia, vomiting, Aged, 80 and over, Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Diseases, Breast Neoplasms, Humans, Liver Function Tests, Liver Neoplasms, Middle Aged, Pilot Projects, Survival Analysis, Tomography, X-Ray Computed, Vinblastine
DOI: 10.1007/s00280-003-0679-8
ISSN: 0344-5704
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Springer
Deposited On: 06 Jan 2014 04:27
Last Modified: 06 Jan 2014 04:31

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page