Familiar drugs may prevent cancer

Sharma, R.A., Gescher, A.J., O'Byrne, K.J., & Steward, W.P. (2001) Familiar drugs may prevent cancer. Postgraduate Medical Journal, 77(910), pp. 492-497.

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Despite positive results in large scale chemoprevention trials, many physicians are unaware of the potential cancer preventive properties of drugs in common usage. The antioestrogen tamoxifen and the selective cyclo-oxygenase-2 inhibitor celecoxib have been licensed in the USA for the chemoprevention of breast and colorectal cancers respectively in selected high risk individuals. Similarly, folate and retinol have been shown to decrease the incidence of colorectal cancer and squamous cell carcinoma of the skin respectively in large scale intervention trials. Other retinoids have proved efficacious in the tertiary chemoprevention of cancers of the breast and head/neck. Epidemiological evidence also exists in favour of aspirin, nonsteroidal anti-inflammatory drugs, and angiotensin converting enzyme inhibitors preventing certain cancers. Phytochemicals may represent less toxic alternatives to these agents. Although some of these drugs are available without prescription and most are not yet licensed for use in cancer chemoprevention, physicians and students of medicine should be aware of this accumulating evidence base. Practitioners should be amenable to patient referral to discuss complex issues such as risk estimation or potential benefit from intervention.

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ID Code: 65682
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Cancer chemoprevention, Cyclo-oxygenase, Folate, Retinoids, Tamoxifen, acetylsalicylic acid, antiestrogen, captopril, celecoxib, curcumin, dipeptidyl carboxypeptidase inhibitor, epigallocatechin gallate, folic acid, herbaceous agent, nonsteroid antiinflammatory agent, prostaglandin synthase, retinoid, amenorrhea, breast cancer, cancer prevention, carcinogenesis, chemoprophylaxis, colorectal cancer, enzyme inhibition, gastrointestinal symptom, head and neck cancer, hot flush, human, primary prevention, review, secondary prevention, skin carcinoma, squamous cell carcinoma, thromboembolism, vagina bleeding, Angiotensin-Converting Enzyme Inhibitors, Anticarcinogenic Agents, Aspirin, Cyclooxygenase Inhibitors, Female, Humans, Male, Neoplasms, Pyrazoles, Raloxifene, Sulfonamides, Vitamin A
DOI: 10.1136/pmj.77.910.492
ISSN: 0032-5473
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 B M J Group
Deposited On: 06 Jan 2014 05:06
Last Modified: 29 Jan 2015 04:50

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