Familiar drugs may prevent cancer
Sharma, R.A., Gescher, A.J., O'Byrne, K.J., & Steward, W.P. (2001) Familiar drugs may prevent cancer. Postgraduate Medical Journal, 77(910), pp. 492-497.
Despite positive results in large scale chemoprevention trials, many physicians are unaware of the potential cancer preventive properties of drugs in common usage. The antioestrogen tamoxifen and the selective cyclo-oxygenase-2 inhibitor celecoxib have been licensed in the USA for the chemoprevention of breast and colorectal cancers respectively in selected high risk individuals. Similarly, folate and retinol have been shown to decrease the incidence of colorectal cancer and squamous cell carcinoma of the skin respectively in large scale intervention trials. Other retinoids have proved efficacious in the tertiary chemoprevention of cancers of the breast and head/neck. Epidemiological evidence also exists in favour of aspirin, nonsteroidal anti-inflammatory drugs, and angiotensin converting enzyme inhibitors preventing certain cancers. Phytochemicals may represent less toxic alternatives to these agents. Although some of these drugs are available without prescription and most are not yet licensed for use in cancer chemoprevention, physicians and students of medicine should be aware of this accumulating evidence base. Practitioners should be amenable to patient referral to discuss complex issues such as risk estimation or potential benefit from intervention.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||Cancer chemoprevention, Cyclo-oxygenase, Folate, Retinoids, Tamoxifen, acetylsalicylic acid, antiestrogen, captopril, celecoxib, curcumin, dipeptidyl carboxypeptidase inhibitor, epigallocatechin gallate, folic acid, herbaceous agent, nonsteroid antiinflammatory agent, prostaglandin synthase, retinoid, amenorrhea, breast cancer, cancer prevention, carcinogenesis, chemoprophylaxis, colorectal cancer, enzyme inhibition, gastrointestinal symptom, head and neck cancer, hot flush, human, primary prevention, review, secondary prevention, skin carcinoma, squamous cell carcinoma, thromboembolism, vagina bleeding, Angiotensin-Converting Enzyme Inhibitors, Anticarcinogenic Agents, Aspirin, Cyclooxygenase Inhibitors, Female, Humans, Male, Neoplasms, Pyrazoles, Raloxifene, Sulfonamides, Vitamin A|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2001 B M J Group|
|Deposited On:||06 Jan 2014 05:06|
|Last Modified:||29 Jan 2015 04:50|
Repository Staff Only: item control page