Angiogenesis as a biomarker and target in cancer chemoprevention

Sharma, Ricky A., Harris, Adrian L., Dalgleish, Angus G., Steward, William P., & O'Byrne, Kenneth J. (2001) Angiogenesis as a biomarker and target in cancer chemoprevention. Lancet Oncology, 2(12), pp. 726-732.

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Angiogenesis, the formation of new blood vessels from existing vasculature, is essential to the late stages of carcinogenesis, allowing tumours to grow beyond 1-2 mm in diameter, invade surrounding tissue, and metastasise. However, more than two decades ago, angiogenesis that preceded neoplastic transformation was seen. Indeed, it can be detected in inflammatory and infectious diseases that increase the risk of developing cancer. Recent advances in fluorescence endoscopy and histological assessment suggest that, for certain cancers, the degree of new blood-vessel formation may differ between the early and late stages of carcinogenic progression. The association between angiogenesis and cancer occurrence, and ease of detection of this process in accessible tissues early in carcinogenesis, mean that angiogenesis fulfils the criteria for a biomarker of the effectiveness of chemopreventive intervention. There is also some evidence that biochemical assays of angiogenic growth factors may after similar potential as surrogate biomarkers. Many natural and synthetic chemopreventive agents in development or in clinical use inhibit new vessel formation in vivo. Validation of angiogenesis as a biomarker for the effectiveness of chemoprevention should further the advancement of some chemopreventive agents.

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ID Code: 65684
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: angiogenic factor, growth factor, angiogenesis, assay, biochemistry, blood vessel, cancer diagnosis, cancer growth, cancer incidence, cancer invasion, cancer prevention, cancer risk, cancer staging, carcinogenesis, chemoprophylaxis, disease association, disease marker, endoscopy, fluorescence, histopathology, in vivo study, infection, inflammatory disease, inhibition kinetics, malignant transformation, metastasis, priority journal, review, tumor growth, validation process, vascularization, Growth Substances, Humans, Neoplasms, Neovascularization, Pathologic
DOI: 10.1016/S1470-2045(01)00586-1
ISSN: 1470-2045
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 The Lancet Publishing Group
Deposited On: 06 Jan 2014 05:10
Last Modified: 06 Jan 2014 05:12

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